Virus Dataset Detail

> Detail information for each sample

Dataset Information
Accession GSE178621
Status 2022/9/8
Title Microglia regulate Zika virus infection in human developing brain and glioma
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary This paper shows that, whereas SOX2+ cells in HDB are highly susceptible to ZKV, SOX2+ primary GBM samples exhibit moderate to high resistance to infection. These datasets address the reasons for this difference, based on infection of primary patient GBM and human developing brain samples with mCherry Zika reporter virus, then FACS sorting the Zika-mCherry positive and negative fractions from each sample for bulk RNA-Sequencing. The primary finding of importance is that Zika resistant GBMs exhibit an immune signature reflecting high levels of infiltration by microglia which are present only in small numbers or absent altogether in human developing brain.
Samples
GSM ID Sample info Characteristics Description
GSM5394569 Embryo.72h.n.2208 tissue:Type_Embryo; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_2208 2208 mCh 72hr Negative
GSM5394570 Embryo.72h.p.2208 tissue:Type_Embryo; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_2208 2208 mCh 72hr Positive
GSM5394571 GBM_HR.48h.n.42 tissue:Type_GBM_HR; infection time:Hours_48; zika mcherry reporter status:PosNeg_n; sample id:ID_42 042 mCh 48hr Negative
GSM5394572 GBM_HR.48h.p.42 tissue:Type_GBM_HR; infection time:Hours_48; zika mcherry reporter status:PosNeg_p; sample id:ID_42 042 mCh 48hr Positive
GSM5394573 GBM_HR.72h.n.42 tissue:Type_GBM_HR; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_42 042 mCh 72hr Negative
GSM5394574 GBM_HR.72h.p.42 tissue:Type_GBM_HR; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_42 042 mCh 72hr Positive
GSM5394575 GBM.48h.n.39 tissue:Type_GBM; infection time:Hours_48; zika mcherry reporter status:PosNeg_n; sample id:ID_39 039 mCh 48hr Negative
GSM5394576 GBM.48h.p.39 tissue:Type_GBM; infection time:Hours_48; zika mcherry reporter status:PosNeg_p; sample id:ID_39 039 mCh 48hr Positive
GSM5394577 GBM.72h.n.39 tissue:Type_GBM; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_39 039 mCh 72hr Negative
GSM5394578 GBM.72h.p.39 tissue:Type_GBM; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_39 039 mCh 72hr Positive
GSM5394579 GBM.72h.n.43 tissue:Type_GBM; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_43 1 - 043 72 hr negative
GSM5394580 GBM.72h.p.43 tissue:Type_GBM; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_43 2- 043 72hr positive
GSM5394581 GBM_MR.72h.n.45 tissue:Type_GBM_MR; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_45 3- 045 72hr negative
GSM5394582 GBM_MR.72h.p.45 tissue:Type_GBM_MR; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_45 4- 045 72hr positive
GSM5394583 GBM_MR.72h.n.46 tissue:Type_GBM_MR; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_46 5- 046 72 hr negative
GSM5394584 GBM_MR.72h.p.46 tissue:Type_GBM_MR; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_46 6- 046 72hr positive
GSM5394585 Embryo.48h.n.2215 tissue:Type_Embryo; infection time:Hours_48; zika mcherry reporter status:PosNeg_n; sample id:ID_2215 7- BRC2215 48hr negative
GSM5394586 Embryo.48h.p.2215 tissue:Type_Embryo; infection time:Hours_48; zika mcherry reporter status:PosNeg_p; sample id:ID_2215 8- BRC2215 48hr positive
GSM5394587 GBM_HR.72h.p.50 tissue:Type_GBM_HR; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_50 050 +
GSM5394588 GBM_HR.72h.n.50 tissue:Type_GBM_HR; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_50 050 -
GSM5394589 GBM_MR.72h.p.51 tissue:Type_GBM_MR; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_51 051 +
GSM5394590 GBM_MR.72h.n.51 tissue:Type_GBM_MR; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_51 051 -
GSM5394591 GBM.72h.p.54 tissue:Type_GBM; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_54 054 +
GSM5394592 GBM.72h.n.54 tissue:Type_GBM; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_54 054 -
GSM5394593 GBM_MR.72h.p.57 tissue:Type_GBM_MR; infection time:Hours_72; zika mcherry reporter status:PosNeg_p; sample id:ID_57 057 +
GSM5394594 GBM_MR.72h.n.57 tissue:Type_GBM_MR; infection time:Hours_72; zika mcherry reporter status:PosNeg_n; sample id:ID_57 057 -
GSM5394595 Embryo.48h.p.2226 tissue:Type_Embryo; infection time:Hours_48; zika mcherry reporter status:PosNeg_p; sample id:ID_2226 BRC 2226 +
GSM5394596 Embryo.48h.n.2226 tissue:Type_Embryo; infection time:Hours_48; zika mcherry reporter status:PosNeg_n; sample id:ID_2226 BRC 2226 -
Platform GPL24676  : Illumina NovaSeq 6000 (Homo sapiens)
Literature 36174572  
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xCell Plot
* p<0.05 ** p<0.01