Gene Information
|
Gene Name
|
AXL |
|
Gene ID
|
558
|
|
Gene Full Name
|
AXL receptor tyrosine kinase |
|
Gene Alias
|
ARK|AXL3|JTK11|Tyro7|UFO |
|
Transcripts
|
ENSG00000167601
|
|
Virus
|
ZIKV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Plasma membrane;Vesicles, Actin filaments; 
|
|
Membrane Info
|
Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins |
|
Uniport_ID
|
P30530
|
|
HGNC ID
|
HGNC:905
|
|
OMIM ID
|
109135 |
|
Summary
|
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021] |
Target gene [AXL] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
| ID |
PMID |
Mutation |
Gene/Protein/Region |
Encoding Gene/Protein |
Disease |
Description |
Detail |
| 1 |
40062839 |
H83R |
prM
|
prM
|
Cell line
|
I
T
|
View |
Target gene [AXL] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE198542
|
RNA-seq |
12 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE176428
|
RNA-seq |
8 |
Illumina MiSeq (Homo sapiens) |
|
GSE78711
|
RNA-seq |
8 |
Illumina MiSeq (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
GSE178621
|
RNA-seq |
28 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE161783
|
Chip-seq;RNA-seq;csRNA-seq |
51 |
Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE105884
|
RNA-seq |
60 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE209698
|
RNA-seq |
16 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE123835
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE160201
|
RNA-seq |
16 |
Illumina NextSeq 500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE161783 - AXL peak across samples
|
Peak Plot
|
|
|
ZIKV Target gene Detail Information
