Gene Name	CNKSR2
Gene ID	22866
Gene Full Name	connector enhancer of kinase suppressor of Ras 2
Gene Alias	CNK2|KSR2|MAGUIN|MRXSHG
Transcripts	ENSG00000149970
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Golgi apparatus, Plasma membrane;
Membrane Info	Disease related genes, Human disease related genes, Predicted intracellular proteins
Uniport_ID	Q8WXI2
HGNC ID	HGNC:19701
OMIM ID	300724
Summary	This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5004619	chrX	0	0	0	0	View
5004728	chrX	0	0	0	0	View
5004747	chrX	8	1	3	12	View
5004748	chrX	12	4	10	26	View
5004751	chrX	4	1	0	5	View
5005682	chrX	0	0	0	0	View
5005931	chrX	0	0	0	0	View
5005933	chrX	0	0	0	0	View
5006144	chrX	3	1	0	4	View
5006429	chrX	2	0	0	2	View
5006440	chrX	39	4	2	45	View
5006681	chrX	12	1	7	20	View
5006691	chrX	3	0	0	3	View
5007829	chrX	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
GSE40774	Expression array	134	Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE143026 - CNKSR2 peak across samples

Peak Plot