Gene Name	IKBKE
Gene ID	9641
Gene Full Name	inhibitor of nuclear factor kappa B kinase subunit epsilon
Gene Alias	IKK-E|IKK-i|IKKE|IKKI
Transcripts	ENSG00000263528
Virus	ZIKV
Gene Type	protein-coding
HPA Location Info	Cytosol;
Membrane Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q14164
HGNC ID	HGNC:14552
OMIM ID	605048
Summary	IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	29379028	A188V	NS1	NS1	Cell line	R I L T	View
2	29379028	V188A	NS1	NS1	Cell line	R I L T	View

Data ID	Experiment type	Sample number	Platform
GSE198542	RNA-seq	12	Illumina NextSeq 500 (Homo sapiens)
GSE176428	RNA-seq	8	Illumina MiSeq (Homo sapiens)
GSE78711	RNA-seq	8	Illumina MiSeq (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE178621	RNA-seq	28	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE161783	Chip-seq;RNA-seq;csRNA-seq	51	Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
E   GSE105884	RNA-seq	60	Illumina HiSeq 2500 (Homo sapiens)
GSE209698	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)
GSE123835	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)
GSE160201	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE105884 - IKBKE expression across samples

Volcano Plot

Bar Plot