Gene Name	IKZF3
Gene ID	22806
Gene Full Name	IKAROS family zinc finger 3
Gene Alias	AIO|AIOLOS|IMD84|ZNFN1A3
Transcripts	ENSG00000161405
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q9UKT9
HGNC ID	HGNC:13178
OMIM ID	606221
Summary	This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5012944	chr17	119	3	0	122	View
5012945	chr17	14	7	0	21	View
5015207	chr17	34	168	98	300	View
5015208	chr17	85	1	0	86	View
5015209	chr17	305	72	9	386	View
5015210	chr17	629	531	217	1377	View
5015211	chr17	63	101	5	169	View
5015212	chr17	29	10	2	41	View
5015213	chr17	118	22	1	141	View
5015214	chr17	235	209	272	716	View
5015215	chr17	33	9	0	42	View
5015216	chr17	133	1	0	134	View
5015217	chr17	200	63	24	287	View
5015218	chr17	33	2	0	35	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE226620	scRNA-seq	30	HiSeq X Ten (Homo sapiens)
GSE139324	scRNA-seq	63	Illumina NextSeq 500 (Homo sapiens)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE164690	scRNA-seq	51	Illumina NextSeq 500 (Homo sapiens)
GSE138080	Expression array	35	Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
S   GSE197461	scRNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens)
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.

> Dataset: GSE197461 - Gene expression in cell subsets