Gene Information
|
Gene Name
|
IRF3 |
|
Gene ID
|
3661
|
|
Gene Full Name
|
interferon regulatory factor 3 |
|
Gene Alias
|
IIAE7 |
|
Transcripts
|
ENSG00000126456
|
|
Virus
|
ZIKV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Cytosol; 
|
|
Membrane Info
|
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
|
Uniport_ID
|
Q14653
|
|
HGNC ID
|
HGNC:6118
|
|
OMIM ID
|
603734 |
|
Summary
|
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020] |
Target gene [IRF3] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [IRF3] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE198542
|
RNA-seq |
12 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE176428
|
RNA-seq |
8 |
Illumina MiSeq (Homo sapiens) |
|
GSE78711
|
RNA-seq |
8 |
Illumina MiSeq (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
GSE178621
|
RNA-seq |
28 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE161783
|
Chip-seq;RNA-seq;csRNA-seq |
51 |
Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE105884
|
RNA-seq |
60 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE209698
|
RNA-seq |
16 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE123835
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE161783 - IRF3 peak across samples
|
Peak Plot
|
|
|
ZIKV Target gene Detail Information
