Gene Name	MAP2K7
Gene ID	5609
Gene Full Name	mitogen-activated protein kinase kinase 7
Gene Alias	JNKK2|MAPKK7|MEK|MEK 7|MKK7|PRKMK7|SAPKK-4|SAPKK4
Transcripts	ENSG00000076984
Virus	KSHV
Gene Type	protein-coding
HPA Location Info	Plasma membrane, Cytosol;
Membrane Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	O14733
HGNC ID	HGNC:6847
OMIM ID	603014
Summary	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	36674756	ORF21 deletion	ORF21	ORF21	Cell line	R T	View
2	36674756	21KD	ORF21	ORF21	Cell line	R T	View

Data ID	Experiment type	Sample number	Platform
GSE232843	RNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE79029	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
GSE280380	RNA-seq	54	Illumina NovaSeq 6000 (Homo sapiens)
GSE158935	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE132777	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE147063	Chip-seq;GRO-seq;4C-seq	10	Illumina NextSeq 500 (Homo sapiens);Illumina Hiseq 2500 (Homo sapiens)
GSE207589	RNA-seq	12	Illumina HiSeq 2000 (Homo sapiens)
GSE241095	RNA-seq	44	Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE135740	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
C   GSE52421	Chip-seq	18	Illumina Genome Analyzer IIx (Homo sapiens)
GSE280006	RNA-seq	14	NextSeq 550 (Homo sapiens)
C   GSE38411	Chip-seq	5	Illumina Genome Analyzer II (Homo sapiens);Illumina Genome Analyzer II (Human herpesvirus 8)
GSE260925	RNA-seq	24	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE56144	Chip-seq;RNA-seq	33	Illumina Genome Analyzer II (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE132777 - MAP2K7 peak across samples

Peak Plot

> Dataset: GSE135740 - MAP2K7 peak across samples

Peak Plot

> Dataset: GSE52421 - MAP2K7 peak across samples

Peak Plot

> Dataset: GSE38411 - MAP2K7 peak across samples

Peak Plot

> Dataset: GSE56144 - MAP2K7 peak across samples

Peak Plot