Virus Dataset Detail

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Dataset Information
Accession GSE260925
Status 2024/7/8
Title Unveiling the Role of KSHV-Infected Human Mesenchymal Stem Cells in Kaposi's Sarcoma Initiation
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Kaposi's sarcoma (KS) may derive from Kaposi's Sarcoma Herpesvirus (KSHV)-infected human Mesenchymal Stem Cells (hMSCs) that migrate to sites characterized by inflammation and angiogenesis, promoting the initiation of KS. By analyzing the RNA sequences of KSHV-infected primary hMSCs, we have identified specific cell subpopulations, mechanisms, and conditions involved in the initial stages of KSHV-induced transformation and reprogramming of hMSCs into KS progenitor cells. Under pro-angiogenic environmental conditions, KSHV can reprogram hMSCs to exhibit gene expression profiles more similar to KS tumors, activating cell cycle progression, cytokine signaling pathways, and endothelial differentiation indicating the involvement of KSHV infection in inducing the Mesenchymal-to-Endothelial (MEndT) transition of hMSCs. This finding underscores the significance of this condition in facilitating KSHV-induced proliferation and reprogramming of hMSCs towards MEndT and closer to KS gene expression profiles, providing further evidence of these cell subpopulations as precursors of KS cells that thrive in a pro-angiogenic environment.
Samples
GSM ID Sample info Characteristics Description
GSM8128112 MSC-Control-KS-LT_1 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:KS media; time:Long-term culture -
GSM8128113 MSC-Control-KS-LT_2 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:KS media; time:Long-term culture -
GSM8128114 MSC-Control-KS-LT_3 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:KS media; time:Long-term culture -
GSM8128115 MSC-Control-KS-ST_1 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:KS media; time:short-term culture -
GSM8128116 MSC-Control-KS-ST_2 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:KS media; time:short-term culture -
GSM8128117 MSC-Control-KS-ST_3 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:KS media; time:short-term culture -
GSM8128118 MSC-Control-MEM-LT_1 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:MEM media; time:Long-term culture -
GSM8128119 MSC-Control-MEM-LT_2 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:MEM media; time:Long-term culture -
GSM8128120 MSC-Control-MEM-LT_3 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:MEM media; time:Long-term culture -
GSM8128121 MSC-Control-MEM-ST_1 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:MEM media; time:short-term culture -
GSM8128122 MSC-Control-MEM-ST_2 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:MEM media; time:short-term culture -
GSM8128123 MSC-Control-MEM-ST_3 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:non-infected; media:MEM media; time:short-term culture -
GSM8128124 MSC-KSHV-KS-LT_1 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:KS media; time:Long-term culture -
GSM8128125 MSC-KSHV-KS-LT_2 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:KS media; time:Long-term culture -
GSM8128126 MSC-KSHV-KS-LT_3 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:KS media; time:Long-term culture -
GSM8128127 MSC-KSHV-KS-ST_1 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:KS media; time:short-term culture -
GSM8128128 MSC-KSHV-KS-ST_2 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:KS media; time:short-term culture -
GSM8128129 MSC-KSHV-KS-ST_3 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:KS media; time:short-term culture -
GSM8128130 MSC-KSHV-MEM-LT_1 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:MEM media; time:Long-term culture -
GSM8128131 MSC-KSHV-MEM-LT_2 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:MEM media; time:Long-term culture -
GSM8128132 MSC-KSHV-MEM-LT_3 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:MEM media; time:Long-term culture -
GSM8128133 MSC-KSHV-MEM-ST_1 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:MEM media; time:short-term culture -
GSM8128134 MSC-KSHV-MEM-ST_2 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:MEM media; time:short-term culture -
GSM8128135 MSC-KSHV-MEM-ST_3 cell line:Primary hMSC; cell type:bone marrow-derived human Mesenchymal Stem Cells; infection status:rKSHV-219 infected; media:MEM media; time:short-term culture -
Platform GPL24676  : Illumina NovaSeq 6000 (Homo sapiens)
Literature 38773828  
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* p<0.05 ** p<0.01