Accession	GSE135740
Status	2020/8/13
Title	Genome-wide maps of chromatin modifications in KSHV-transformed primary effusion lymphoma cell lines
Organism	Homo sapiens
Experiment type	Genome binding/occupancy profiling by high throughput sequencing
Summary	The Kaposi's sarcoma-associated herpesviruses causes several cancers including Kaposi's sarcoma and primary effusion lymphoma (PEL). Our work reveals that the cellular transcription factors interferon regulatory factor 4 (IRF4) and basic leucine zipper ATF-like transcription factor (BATF), as well as the viral interferon regulatory factor 3 (vIRF3) are critical oncogenic dependencies specific to PEL cell lines. To understand the functions of these transcription factors, we performed ChIP-Seq on these proteins and other histone modifications in different PEL cell lines. Our results reveal that these oncogenic factors may cooperate to regulate the expression of the same mRNAs through promoter, enhancer, and superenhancer elements.
Samples	GSM ID Sample info Characteristics Description GSM4027074 BC3 H3K27ac chip antibody:H3K27ac (Abcam #ab4729) - GSM4027065 BC1 Input chip antibody:none - GSM4027066 BC1 H3K27ac chip antibody:H3K27ac (Abcam #ab4729) - GSM4027067 BCBL1 Input chip antibody:none - GSM4027068 BCBL1 H3K27ac chip antibody:H3K27ac (Abcam #ab4729) - GSM4027069 BC3 Input for CTCF, H3K4me3 chip antibody:none - GSM4027070 BC3 CTCF chip antibody:CTCF (Cell Signaling #3418) - GSM4027071 BC3 H3K4me3 chip antibody:H3K4me3 (Millipore #04-745) - GSM4027072 BC3 Input for H3K4me1, H3K27ac chip antibody:none - GSM4027073 BC3 H3K4me1 chip antibody:H3K4me1 (Cell Signaling #5326) -
Platform	GPL11154  GPL18573  : Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
Literature	32843547
Download	Download Genome Binding/Occupancy Profiling Analysis Data