Gene Name	PDCD1LG2
Gene ID	80380
Gene Full Name	programmed cell death 1 ligand 2
Gene Alias	B7DC|Btdc|CD273|PD-L2|PDCD1L2|PDL2|bA574F11.2
Transcripts	ENSG00000197646
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Cytosol;Secreted - unknown location;
Membrane Info	Cancer-related genes, CD markers, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	Q9BQ51
HGNC ID	HGNC:18731
OMIM ID	605723
Summary	Involved in negative regulation of activated T cell proliferation; negative regulation of interleukin-10 production; and negative regulation of type II interferon production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Apr 2025]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5001607	chr9	24	1	0	25	View
5003584	chr9	2	1	0	3	View
5003585	chr9	2	1	0	3	View
5016429	chr9	19	6	2	27	View
5016855	chr9	4	1	0	5	View
5016856	chr9	1	2	0	3	View
5017846	chr9	1236	2672	1943	5851	View
5017847	chr9	1200	2581	1926	5707	View
5017848	chr9	2036	402	241	2679	View
5017849	chr9	19	0	0	19	View
5017851	chr9	156	57	77	290	View
5017857	chr9	3	33	3	39	View
5017858	chr9	123	12	44	179	View
5017859	chr9	5	0	1	6	View
5017860	chr9	36	1	0	37	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE226620	scRNA-seq	30	HiSeq X Ten (Homo sapiens)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
M   TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE199029	Variation;RNA-seq	44	NanoString Human nCounter PanCancer IO360 Panel
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Methylation profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE183048 - PDCD1LG2 peak across samples

Peak Plot

> Dataset: GSE143026 - PDCD1LG2 peak across samples

Peak Plot