|
Dataset Information
| Accession |
GSE199029
|
| Status |
2022/4/2 |
| Title |
Integrative genome analysis reveals low T cell infiltration as the primary feature of tobacco use in HPV(+) oropharyngeal cancer |
| Organism |
Homo sapiens |
| Experiment type |
Other |
| Summary |
Tobacco use is an independent adverse prognostic feature in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). Despite this, the biologic features associated with tobacco use have not been systematically investigated in this population. We sought to characterize the genomic and immunologic features of HPV(+) OPSCC associated with tobacco use and adverse oncologic outcomes. Whole exome sequencing of 47 primary HPV(+) OPSCC tumors was performed to investigate mutational differences associated with tobacco exposure. To characterize the tumor immune microenvironment (TIME), targeted mRNA hybridization was performed. Low expression of transcripts in a T cell-inflamed gene expression profile (TGEP) was associated with tobacco use at the time of diagnosis and lower overall and disease-free survival. Tobacco use was associated with an increased proportion of T>C substitutions and a lower proportion of mutational signatures typically observed in HPV(+) OPSCC tumors, but was not associated with increases in mutational burden or the rate of recurrent oncogenic mutations. Our work suggests that rather than increased mutational burden, tobacco’s primary and clinically relevant association in HPV(+) OPSCC is immunosuppression of the tumor immune microenvironment. |
| Samples |
| GSM ID |
Sample info |
Characteristics |
Description |
|
GSM5962724
|
Study participant 100-026 |
age(years):45; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):1; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):961; vital_status(0=alive,1=dead):0; os_time(days):961; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962725
|
Study participant 100-047 |
age(years):52; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):4; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):1399; vital_status(0=alive,1=dead):0; os_time(days):1399; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962726
|
Study participant 100-057 |
age(years):54; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):4; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):1391; vital_status(0=alive,1=dead):0; os_time(days):1391; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962727
|
Study participant 100-062 |
age(years):55; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):1; recurrence_time(days):756; vital_status(0=alive,1=dead):1; os_time(days):1442; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962728
|
Study participant 100-068 |
age(years):52; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):1; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):4; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):1748; vital_status(0=alive,1=dead):1; os_time(days):1748; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962729
|
Study participant 100-070 |
age(years):62; sex (1=male,2=female):2; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):1; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):5; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):3; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):2849; vital_status(0=alive,1=dead):0; os_time(days):2849; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962730
|
Study participant 100-072 |
age(years):71; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):1; recurrence_time(days):1091; vital_status(0=alive,1=dead):0; os_time(days):2740; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962731
|
Study participant 100-1006 |
age(years):66; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):761; vital_status(0=alive,1=dead):0; os_time(days):761; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962732
|
Study participant 100-1026 |
age(years):66; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):427; vital_status(0=alive,1=dead):1; os_time(days):427; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962733
|
Study participant 100-1033 |
age(years):79; sex (1=male,2=female):2; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):2; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):362; vital_status(0=alive,1=dead):0; os_time(days):362; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962734
|
Study participant 100-1038 |
age(years):45; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):636; vital_status(0=alive,1=dead):0; os_time(days):636; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962735
|
Study participant 100-1040 |
age(years):51; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):1; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):1; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):728; vital_status(0=alive,1=dead):0; os_time(days):728; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962736
|
Study participant 100-1050 |
age(years):61; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):688; vital_status(0=alive,1=dead):0; os_time(days):688; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962737
|
Study participant 100-1076 |
age(years):69; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):652; vital_status(0=alive,1=dead):0; os_time(days):652; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962738
|
Study participant 100-1086 |
age(years):56; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):1; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):4; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):1; recurrence_time(days):180; vital_status(0=alive,1=dead):0; os_time(days):694; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962739
|
Study participant 100-1104 |
age(years):61; sex (1=male,2=female):2; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):4; clin_n_stage(1=n0,2=n1,3=n2,4=n3):1; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):677; vital_status(0=alive,1=dead):0; os_time(days):677; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962740
|
Study participant 100-1106 |
age(years):58; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):1; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):686; vital_status(0=alive,1=dead):0; os_time(days):686; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962741
|
Study participant 100-1107 |
age(years):63; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):4; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):3; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):624; vital_status(0=alive,1=dead):0; os_time(days):624; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962742
|
Study participant 100-1114 |
age(years):51; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):1; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):571; vital_status(0=alive,1=dead):0; os_time(days):571; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962743
|
Study participant 100-1145 |
age(years):64; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):2; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):455; vital_status(0=alive,1=dead):0; os_time(days):455; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962744
|
Study participant 100-1146 |
age(years):54; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):519; vital_status(0=alive,1=dead):0; os_time(days):519; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962745
|
Study participant 100-1149 |
age(years):50; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):2; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):1; recurrence_time(days):406; vital_status(0=alive,1=dead):0; os_time(days):509; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962746
|
Study participant 100-1158 |
age(years):67; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):1; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):2; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):491; vital_status(0=alive,1=dead):0; os_time(days):491; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962747
|
Study participant 100-1164 |
age(years):60; sex (1=male,2=female):2; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):2; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):539; vital_status(0=alive,1=dead):0; os_time(days):539; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962748
|
Study participant 100-1171 |
age(years):60; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):556; vital_status(0=alive,1=dead):0; os_time(days):556; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962749
|
Study participant 100-1177 |
age(years):79; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):1; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):376; vital_status(0=alive,1=dead):0; os_time(days):376; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962750
|
Study participant 100-1189 |
age(years):77; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):3; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):4; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):342; vital_status(0=alive,1=dead):0; os_time(days):342; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
- |
|
GSM5962751
|
Study participant 100-1211 |
age(years):49; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):5; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):3; recurrence(0=no recurrence,1=recurrence):1; recurrence_time(days):477; vital_status(0=alive,1=dead):0; os_time(days):504; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962752
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Study participant 100-126 |
age(years):47; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):4; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):2005; vital_status(0=alive,1=dead):0; os_time(days):2005; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962753
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Study participant 100-136 |
age(years):45; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):2; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):1; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):1811; vital_status(0=alive,1=dead):0; os_time(days):1811; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962754
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Study participant 100-162 |
age(years):54; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):2548; vital_status(0=alive,1=dead):0; os_time(days):2548; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962755
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Study participant 100-346 |
age(years):57; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):4; clin_n_stage(1=n0,2=n1,3=n2,4=n3):4; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):3; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):1596; vital_status(0=alive,1=dead):0; os_time(days):1596; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962756
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Study participant 100-347 |
age(years):53; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):5; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):2; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):4; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):164; vital_status(0=alive,1=dead):1; os_time(days):164; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962757
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Study participant 100-352 |
age(years):48; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):2070; vital_status(0=alive,1=dead):0; os_time(days):2070; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962758
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Study participant 100-378 |
age(years):79; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):6; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):3; recurrence(0=no recurrence,1=recurrence):1; recurrence_time(days):312; vital_status(0=alive,1=dead):0; os_time(days):336; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962759
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Study participant 100-406 |
age(years):71; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):2043; vital_status(0=alive,1=dead):0; os_time(days):2043; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962760
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Study participant 100-740 |
age(years):53; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):1; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):2; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):1; recurrence_time(days):622; vital_status(0=alive,1=dead):1; os_time(days):869; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962761
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Study participant 100-796 |
age(years):56; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):1349; vital_status(0=alive,1=dead):0; os_time(days):1349; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962762
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Study participant 100-797 |
age(years):62; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):2; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):297; vital_status(0=alive,1=dead):0; os_time(days):297; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962763
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Study participant 100-883 |
age(years):51; sex (1=male,2=female):2; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):2; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):1252; vital_status(0=alive,1=dead):0; os_time(days):1252; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962764
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Study participant 100-905 |
age(years):58; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):3; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):1; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):1089; vital_status(0=alive,1=dead):0; os_time(days):1089; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962765
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Study participant 100-913 |
age(years):53; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):6; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):3; recurrence(0=no recurrence,1=recurrence):1; recurrence_time(days):259; vital_status(0=alive,1=dead):1; os_time(days):777; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962766
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Study participant 100-931 |
age(years):61; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):2; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):2; clin_n_stage(1=n0,2=n1,3=n2,4=n3):3; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):2; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):894; vital_status(0=alive,1=dead):0; os_time(days):894; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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GSM5962767
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Study participant 100-988 |
age(years):58; sex (1=male,2=female):1; race (1=white,2=asian):1; tobacco (1=current,2=former,3=never):1; subsite(1=tonsils and pillars,2=base of tongue,3=pharyngeal overlapping):2; clin_t_stage(1=t0,2=t1,3=t2,4=t3,5=t4a,6=t4b):3; clin_n_stage(1=n0,2=n1,3=n2,4=n3):4; clin_m_stage(1=m0,2=m1):1; clin_stage(1=stage i,2=stage ii,3=stage iii,4=stage iv):3; recurrence(0=no recurrence,1=recurrence):0; recurrence_time(days):556; vital_status(0=alive,1=dead):0; os_time(days):556; disease state:human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC); tissue:HPV(+) OPSCC tumor |
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| Platform |
GPL32069 : NanoString Human nCounter PanCancer IO360 Panel |
| Literature |
35494251 |
| Download |
Download Expression Analysis Data
|
|
Virus Dataset Detail
