Gene Name	PDCD1LG2
Gene ID	80380
Gene Full Name	programmed cell death 1 ligand 2
Gene Alias	B7DC|Btdc|CD273|PD-L2|PDCD1L2|PDL2|bA574F11.2
Transcripts	ENSG00000197646
Virus	ZIKV
Gene Type	protein-coding
HPA Location Info	Cytosol;Secreted - unknown location;
Membrane Info	Cancer-related genes, CD markers, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	Q9BQ51
HGNC ID	HGNC:18731
OMIM ID	605723
Summary	Involved in negative regulation of activated T cell proliferation; negative regulation of interleukin-10 production; and negative regulation of type II interferon production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Apr 2025]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	39986659	S139N	prM	prM	Cell line	G R I T	View

Data ID	Experiment type	Sample number	Platform
E   GSE198542	RNA-seq	12	Illumina NextSeq 500 (Homo sapiens)
GSE176428	RNA-seq	8	Illumina MiSeq (Homo sapiens)
GSE78711	RNA-seq	8	Illumina MiSeq (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE178621	RNA-seq	28	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE161783	Chip-seq;RNA-seq;csRNA-seq	51	Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE105884	RNA-seq	60	Illumina HiSeq 2500 (Homo sapiens)
GSE209698	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)
GSE123835	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)
GSE160201	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE198542 - PDCD1LG2 expression across samples

Volcano Plot

Bar Plot