Gene Information
|
Gene Name
|
PDIA3 |
|
Gene ID
|
2923
|
|
Gene Full Name
|
protein disulfide isomerase family A member 3 |
|
Gene Alias
|
ER60|ERp57|ERp60|ERp61|GRP57|GRP58|HEL-S-269|HEL-S-93n|HsT17083|P58|PI-PLC |
|
Transcripts
|
ENSG00000167004
|
|
Virus
|
ZIKV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Endoplasmic reticulum;Intracellular and membrane; 
|
|
Membrane Info
|
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
|
Uniport_ID
|
P30101
|
|
HGNC ID
|
HGNC:4606
|
|
OMIM ID
|
602046 |
|
Summary
|
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016] |
Target gene [PDIA3] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
| ID |
PMID |
Mutation |
Gene/Protein/Region |
Encoding Gene/Protein |
Disease |
Description |
Detail |
| 1 |
30391636 |
S135A |
NS3
|
NS3
|
Cell line
|
T
|
View |
Target gene [PDIA3] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
E GSE198542
|
RNA-seq |
12 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE176428
|
RNA-seq |
8 |
Illumina MiSeq (Homo sapiens) |
|
GSE78711
|
RNA-seq |
8 |
Illumina MiSeq (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
GSE178621
|
RNA-seq |
28 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE161783
|
Chip-seq;RNA-seq;csRNA-seq |
51 |
Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE105884
|
RNA-seq |
60 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE209698
|
RNA-seq |
16 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE123835
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE160201
|
RNA-seq |
16 |
Illumina NextSeq 500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: GSE198542 - PDIA3 expression across samples
|
Volcano Plot
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Bar Plot
|
|
|
ZIKV Target gene Detail Information
