Gene Name	SOX10
Gene ID	6663
Gene Full Name	SRY-box transcription factor 10
Gene Alias	DOM|PCWH|SOX-10|WS2E|WS4|WS4C
Transcripts	ENSG00000100146
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;
Membrane Info	Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	P56693
HGNC ID	HGNC:11190
OMIM ID	602229
Summary	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	32677948	A7376G	LCR		Squamous Intraepithelial Lesions Cervical Intraepithelial Neoplasia	G L T	View
2	32677948	T7791A	LCR		Squamous Intraepithelial Lesions Cervical Intraepithelial Neoplasia	G L T	View
3	32677948	A7793C	LCR		Squamous Intraepithelial Lesions Cervical Intraepithelial Neoplasia	G L T	View
4	32677948	C7265G	LCR		Squamous Intraepithelial Lesions Cervical Intraepithelial Neoplasia	G L T	View
5	29695285	C7265G	LCR		Papillomavirus Infections	G R S L T	View
6	29695285	C7266T	LCR		Papillomavirus Infections	G R S L T	View

Data ID	Experiment type	Sample number	Platform
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
E   GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
E   GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE199029	Variation;RNA-seq	44	NanoString Human nCounter PanCancer IO360 Panel
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE55550 - SOX10 expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE55542 - SOX10 expression across samples

Volcano Plot

Bar Plot