Gene Information
|
Gene Name
|
STAT2 |
|
Gene ID
|
6773
|
|
Gene Full Name
|
signal transducer and activator of transcription 2 |
|
Gene Alias
|
IMD44|ISGF-3|P113|PTORCH3|STAT113 |
|
Transcripts
|
ENSG00000170581
|
|
Virus
|
ZIKV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Cytosol, Mid piece;Plasma membrane, Principal piece; 
|
|
Membrane Info
|
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
|
Uniport_ID
|
P52630
|
|
HGNC ID
|
HGNC:11363
|
|
OMIM ID
|
600556 |
|
Summary
|
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020] |
Target gene [STAT2] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [STAT2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE198542
|
RNA-seq |
12 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE176428
|
RNA-seq |
8 |
Illumina MiSeq (Homo sapiens) |
|
GSE78711
|
RNA-seq |
8 |
Illumina MiSeq (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
GSE178621
|
RNA-seq |
28 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE161783
|
Chip-seq;RNA-seq;csRNA-seq |
51 |
Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE105884
|
RNA-seq |
60 |
Illumina HiSeq 2500 (Homo sapiens) |
|
E GSE209698
|
RNA-seq |
16 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE123835
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
|
E GSE160201
|
RNA-seq |
16 |
Illumina NextSeq 500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: GSE209698 - STAT2 expression across samples
|
Volcano Plot
|
Bar Plot
|
> Dataset: GSE160201 - STAT2 expression across samples
|
Volcano Plot
|
Bar Plot
|
|
|
ZIKV Target gene Detail Information
