All Curated Mutation Sites in SARS-CoV-2 
Back to Mutation Home

 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in SARS-CoV-2 related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a
  
ORF1b
  
ORF3a
  
3CLpro
  
3'UTR
  
5'UTR
  
RBD
  
ORF7b-ORF8
  
upstream of N
  
Furin cleavage site
  
E
  
endoRNase
  
Exonuclease
  
S
  
NSP13
  
NSP3
  
M
  
Mpro
  
Methyltransferase
  
N
  
NSP14
  
NSP12
  
Non-coding region
  
NP
  
NS3
  
NS7a
  
NS7b
  
NS8
  
NSP5
  
NSP1
  
NSP10
  
NSP11
  
NSP15
  
NSP16
  
NSP2
  
NSP4
  
NSP6
  
NSP7
  
NSP8
  
NSP9
  
NTD
  
ORF8
  
ORF1ab
  
ORF9b
  
ORF10
  
ORF3
  
ORF6
  
ORF7a
  
ORF7b
  
ORF9
  
ORF9c
  
PLpro
  
RdRp
  
RBM
  
Replicase
  
RNA primase
  

Keyword: E
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 39048693 V5L
E
E
Cell line
R
L
View
2 39048693 V5F
E
E
Cell line
R
L
View
3 39048693 F26L
E
E
Cell line
R
L
View
4 39048693 G26257C
E
E
Cell line
R
L
View
5 39048693 G26257T
E
E
Cell line
R
L
View
6 39048693 T26320C
E
E
Cell line
R
L
View
7 36539656 S68F
E
E
Cell line
S
L
View
8 37796123 T223I
E
E
COVID-19
Cell line
G
R
View
9 35989365 T9I
E
E

G
View
10 37093365 T9I
E
E

G
View
11 36537060 C26270T
E
E

G
View
12 36537060 T9I
E
E

G
View
13 36454775 P71L
E
E

G
L
View
14 36548384 L21F
E
E

R
L
View
15 36548384 S68P
E
E

R
L
View
16 36548384 P71L
E
E

R
L
View
17 35538074 L73F
E
E

R
I
C
View
18 35726918 V57F
E
E

R
S
L
View
19 35966675 T9I
E
E
COVID-19
G
R
S
C
L
View
20 36755883 T9I
E
E
COVID-19
G
R
L
View
21 37737624 C26270T
E
E
COVID-19
G
S
L
View
22 37737624 T9I
E
E
COVID-19
G
S
L
View
23 37965255 T91I
E
E
COVID-19
G
R
C
L
View
24 37275159 T9I
E
E
COVID-19
G
R
S
C
L
View
25 35128118 V5F
E
E
COVID-19
G
R
L
View
26 38601946 C26408T
E
E
COVID-19
G
R
C
L
View
27 38601946 S55F
E
E
COVID-19
G
R
C
L
View
28 37243279 L21I
E
E
COVID-19
G
R
S
C
L
View
29 37243279 S68F
E
E
COVID-19
G
R
S
C
L
View
30 37243279 S68P
E
E
COVID-19
G
R
S
C
L
View
31 36687433 P71L
E
E
COVID-19
G
R
S
L
View
32 38605705 C26408T
E
E
COVID-19
G
R
S
C
L
View
33 38605705 S55F
E
E
COVID-19
G
R
S
C
L
View
34 37744926 A26295T
E
E
COVID-19
G
R
S
C
L
View
35 37376693 C26270T
E
E
COVID-19
G
R
S
L
View
36 37376693 T9I
E
E
COVID-19
G
R
S
L
View
37 36755883 T11A
E
E
COVID-19
G
R
L
View
38 37224159 C26270T
E
E
COVID-19
G
R
L
View
39 37224159 A26275G
E
E
COVID-19
G
R
L
View
40 37224159 T11A
E
E
COVID-19
G
R
L
View
41 37224159 T9I
E
E
COVID-19
G
R
L
View
42 39227954 T30I
E
E
COVID-19
G
R
L
View
43 34634791 V62F
E
E
COVID-19
G
R
S
View
44 34634791 L21F
E
E
COVID-19
G
R
S
View
45 34634791 P71L
E
E
COVID-19
G
R
S
View
46 37692895 T30I
E
E
COVID-19
G
R
C
View
47 34943523 C26415T
E
E
COVID-19
G
R
L
View
48 35992703 V62F
E
E
COVID-19
G
L
View
49 38601946 C26305T
E
E
COVID-19
G
R
C
L
View
50 38601946 L21F
E
E
COVID-19
G
R
C
L
View
51 38605705 C26270T
E
E
COVID-19
G
R
S
C
L
View
52 38605705 T9I
E
E
COVID-19
G
R
S
C
L
View
53 38632523 C26270T
E
E
COVID-19
G
R
L
View
54 38632523 C26408T
E
E
COVID-19
G
R
L
View
55 38632523 E9I
E
E
COVID-19
G
R
L
View
56 38632523 S55F
E
E
COVID-19
G
R
L
View
57 36090111 L21F
E
E
COVID-19
R
C
L
View
58 36841805 T9I
E
E
COVID-19
R
View
59 37849762 T11A
E
E
COVID-19
R
S
L
View
60 37849762 T9I
E
E
COVID-19
R
S
L
View
61 36672914 T9I
E
E
COVID-19
C
L
View
62 35996593 T30I
E
E
COVID-19
R
L
View
63 36528612 L21F
E
E
COVID-19
R
View
64 36528612 L21V
E
E
COVID-19
R
View
65 36528612 V58F
E
E
COVID-19
R
View
66 36528612 P71L
E
E
COVID-19
R
View
67 36528612 V62F
E
E
COVID-19
R
View
68 36528612 T9I
E
E
COVID-19
R
View
69 36560780 P71L
E
E
COVID-19
View
70 35707124 L73I
E
E
COVID-19
R
L
View
71 37903828 T9I
E
E
COVID-19
R
L
View
72 37903828 P71L
E
E
COVID-19
R
L
View
73 37903828 P71S
E
E
COVID-19
R
L
View
74 37903828 R69G
E
E
COVID-19
R
L
View
75 37903828 T30I
E
E
COVID-19
R
L
View
76 37903828 V49L
E
E
COVID-19
R
L
View
77 36474565 T9I
E
E
COVID-19
R
View
78 36474565 E8D
E
E
COVID-19
R
View
79 36474565 P71L
E
E
COVID-19
R
View
80 36474565 S55F
E
E
COVID-19
R
View
81 36474565 V62F
E
E
COVID-19
R
View
82 36474565 L21F
E
E
COVID-19
R
View
83 36474565 V58F
E
E
COVID-19
R
View
84 36474565 S68F
E
E
COVID-19
R
View
85 36474565 L73F
E
E
COVID-19
R
View
86 36474565 S16G
E
E
COVID-19
R
View
87 36474565 V70F
E
E
COVID-19
R
View
88 36474565 V24A
E
E
COVID-19
R
View
89 36474565 V49L
E
E
COVID-19
R
View
90 36474565 R69I
E
E
COVID-19
R
View
91 36474565 A41V
E
E
COVID-19
R
View
92 36474565 D72G
E
E
COVID-19
R
View
93 36474565 N66S
E
E
COVID-19
R
View
94 36474565 R61L
E
E
COVID-19
R
View
95 36474565 S50I
E
E
COVID-19
R
View
96 36474565 T30I
E
E
COVID-19
R
View
97 36474565 F23L
E
E
COVID-19
R
View
98 36474565 V75L
E
E
COVID-19
R
View
99 33385461 T55S
E
E
COVID-19
R
S
View
100 33385461 V56F
E
E
COVID-19
R
S
View
101 33385461 E69R
E
E
COVID-19
R
S
View
102 33385461 70delG
E
E
COVID-19
R
S
View
103 35197985 A22D
E
E
COVID-19
R
L
View
104 35197985 A36V
E
E
COVID-19
R
L
View
105 35208920 V5F
E
E
COVID-19
R
L
View
106 33760807 V5A
E
E
COVID-19
R
S
L
View
107 33760807 V5G
E
E
COVID-19
R
S
L
View
108 33760807 S6W
E
E
COVID-19
R
S
L
View
109 36819024 L27F
E
E
COVID-19
L
View
110 36819024 L21F
E
E
COVID-19
L
View
111 39660912 T9I
E
E
Cell line
G
View
112 36870749 L28P
E
E
Cell line
G
L
View
113 36870749 T26327C
E
E
Cell line
G
L
View
Contents
Description

The table shows all curated mutation sites of SARS-CoV-2 in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.