All Curated Mutation Sites in SARS-CoV-2

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The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in SARS-CoV-2 related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.

Browse Data by Virus Gene/Protein/Region, Disease OR Description

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Virus Gene/Protein

Disease

Description

For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

Furin cleavage site

Methyltransferase

Non-coding region

Keyword: PLpro

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	38004723	A1803V	PLpro	ORF1a		G R S C L	View
2	38004723	A949T	PLpro	ORF1a		G R S C L	View
3	38004723	D1809N	PLpro	ORF1a		G R S C L	View
4	38004723	S370L	PLpro	ORF1a		G R S C L	View
5	38004723	A1711V	PLpro	ORF1a		G R S C L	View
6	38004723	G489S	PLpro	ORF1a		G R S C L	View
7	38004723	T24I	PLpro	ORF1a		G R S C L	View
8	38004723	V1069I	PLpro	ORF1a		G R S C L	View
9	38004723	K1330E	PLpro	ORF1a		G R S C L	View
10	38004723	A534V	PLpro	ORF1a		G R S C L	View
11	38004723	T1797I	PLpro	ORF1a		G R S C L	View
12	38004723	T1830I	PLpro	ORF1a		G R S C L	View
13	38004723	G307C	PLpro	ORF1a		G R S C L	View
14	38004723	K408N	PLpro	ORF1a		G R S C L	View
15	38004723	V348L	PLpro	ORF1a		G R S C L	View
16	38004723	I1192T	PLpro	ORF1a		R S C L	View
17	38004723	I1672T	PLpro	ORF1a		R S C L	View
18	38004723	I458T	PLpro	ORF1a		R S C L	View
19	38004723	K1155R	PLpro	ORF1a		R S C L	View
20	38004723	M988I	PLpro	ORF1a		R S C L	View
21	38004723	R1518K	PLpro	ORF1a		R S C L	View
22	38004723	R352C	PLpro	ORF1a		R S C L	View
23	38004723	S126L	PLpro	ORF1a		R S C L	View
24	38004723	T1022I	PLpro	ORF1a		R S C L	View
25	38004723	T936N	PLpro	ORF1a		R S C L	View
26	38004723	V1229F	PLpro	ORF1a		R S C L	View
27	37243279	T428I	PLpro	ORF1a	COVID-19	G R S C L	View
28	37243279	T819I	PLpro	ORF1a	COVID-19	G R S C L	View
29	37243279	T1639A	PLpro	ORF1a	COVID-19	G R S C L	View
30	38791536	S830P	PLpro	ORF1a	COVID-19	R L	View
31	38791536	T976A	PLpro	ORF1a	COVID-19	R L	View
32	36409737	A145D	PLpro	ORF1a	COVID-19		View
33	36409737	G163C	PLpro	ORF1a	COVID-19		View
34	36409737	A246T	PLpro	ORF1a	COVID-19		View
35	36409737	E161A	PLpro	ORF1a	COVID-19		View
36	36409737	T291I	PLpro	ORF1a	COVID-19		View
37	36409737	E161D	PLpro	ORF1a	COVID-19		View
38	36409737	P247S	PLpro	ORF1a	COVID-19		View
39	36409737	E161G	PLpro	ORF1a	COVID-19		View
40	36409737	L162S	PLpro	ORF1a	COVID-19		View
41	36409737	G163S	PLpro	ORF1a	COVID-19		View
42	36409737	V165I	PLpro	ORF1a	COVID-19		View
43	36409737	A246V	PLpro	ORF1a	COVID-19		View
44	36409737	P247L	PLpro	ORF1a	COVID-19		View
45	36409737	P247Q	PLpro	ORF1a	COVID-19		View
46	36409737	P247T	PLpro	ORF1a	COVID-19		View
47	36409737	P248S	PLpro	ORF1a	COVID-19		View
48	36409737	E263D	PLpro	ORF1a	COVID-19		View
49	36409737	Y264H	PLpro	ORF1a	COVID-19		View
50	36409737	T265A	PLpro	ORF1a	COVID-19		View
51	36409737	Y268C	PLpro	ORF1a	COVID-19		View
52	36409737	N267D	PLpro	ORF1a	COVID-19		View
53	36409737	N267S	PLpro	ORF1a	COVID-19		View
54	36409737	Y268H	PLpro	ORF1a	COVID-19		View
55	36409737	Q269K	PLpro	ORF1a	COVID-19		View
56	36409737	T277I	PLpro	ORF1a	COVID-19		View
57	36409737	Q269R	PLpro	ORF1a	COVID-19		View
58	36409737	T301A	PLpro	ORF1a	COVID-19		View
59	36409737	T301S	PLpro	ORF1a	COVID-19		View
60	32895623	C111S	PLpro	ORF1a	COVID-19		View
61	36145442	A146D	PLpro	ORF1a	COVID-19		View
62	36145442	P78L	PLpro	ORF1a	COVID-19		View
63	36145442	K233Q	PLpro	ORF1a	COVID-19		View
64	36145442	K93N	PLpro	ORF1a	COVID-19		View
65	36145442	E162D	PLpro	ORF1a	COVID-19		View
66	34548835	A249V	PLpro	ORF1a	COVID-19	R L	View
67	34548835	D108G	PLpro	ORF1a	COVID-19	R L	View
68	37181765	C270K	PLpro	ORF1a	COVID-19		View
69	37181765	C270R	PLpro	ORF1a	COVID-19		View
70	37181765	C270Y	PLpro	ORF1a	COVID-19		View
71	37181765	H272H	PLpro	ORF1a	COVID-19		View
72	36155070	P132H	PLpro	ORF1a	Cell line	G	View

Contents
Description

The table shows all curated mutation sites of SARS-CoV-2 in each literature

Table Description Column Note

D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.

G
The study mentioned the virus genotype/subtype information.

R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.

S
The study provided sequence information or accession numbers.

L
The study provided the geographic region/country of data origin.

C
The study provided clinical baseline information.

I
The study involved information related to immune.

T
The study involved host target genes.