Gene Name	CASP1
Gene ID	834
Gene Full Name	caspase 1
Gene Alias	ICE|IL1BC|P45
Transcripts	ENSG00000137752
Virus	KSHV
Gene Type	protein-coding
HPA Location Info	Cytosol;Nucleoplasm;
Membrane Info	Cancer-related genes, Enzymes, Predicted intracellular proteins
Uniport_ID	P29466
HGNC ID	HGNC:1499
OMIM ID	147678
Summary	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	37364111	F444A	SOX	ORF37	Cell line	I T	View
2	37364111	Y443A	SOX	ORF37	Cell line	I T	View

Data ID	Experiment type	Sample number	Platform
GSE232843	RNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE79029	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE202670	Chip-seq	14	Illumina Genome Analyzer (Homo sapiens)
GSE280380	RNA-seq	54	Illumina NovaSeq 6000 (Homo sapiens)
GSE158935	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE132777	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE147063	Chip-seq;GRO-seq;4C-seq	10	Illumina NextSeq 500 (Homo sapiens);Illumina Hiseq 2500 (Homo sapiens)
GSE207589	RNA-seq	12	Illumina HiSeq 2000 (Homo sapiens)
GSE241095	RNA-seq	44	Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE135740	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
C   GSE52421	Chip-seq	18	Illumina Genome Analyzer IIx (Homo sapiens)
GSE280006	RNA-seq	14	NextSeq 550 (Homo sapiens)
C   GSE38411	Chip-seq	5	Illumina Genome Analyzer II (Homo sapiens);Illumina Genome Analyzer II (Human herpesvirus 8)
GSE260925	RNA-seq	24	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE56144	Chip-seq;RNA-seq	33	Illumina Genome Analyzer II (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE202670 - CASP1 peak across samples

Peak Plot

> Dataset: GSE132777 - CASP1 peak across samples

Peak Plot

> Dataset: GSE135740 - CASP1 peak across samples

Peak Plot

> Dataset: GSE52421 - CASP1 peak across samples

Peak Plot

> Dataset: GSE38411 - CASP1 peak across samples

Peak Plot

> Dataset: GSE56144 - CASP1 peak across samples

Peak Plot