HPV Target gene Detail Information

> CD274 Gene Search Result


Gene Information
Gene Name CD274
Gene ID 29126
Gene Full Name CD274 molecule
Gene Alias B7-H|B7H1|PD-L1|PDCD1L1|PDCD1LG1|PDL1|hPD-L1
Transcripts ENSG00000120217
Virus HPV
Gene Type protein-coding
HPA Location Info Plasma membrane, Actin filaments;Nucleoplasm;Secreted - unknown location;
Membrane Info Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Predicted membrane proteins, Transporters
Uniport_ID Q9NZQ7
HGNC ID HGNC:17635
OMIM ID 605402
Summary This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Target gene [CD274] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5001150 chr9 15 33 0 48 View
5001747 chr9 18 4 2 24 View
5001853 chr9 15 4 2 21 View
5001855 chr9 15 4 2 21 View
5003051 chr9 5 1 0 6 View
5003207 chr9 5 0 0 5 View
5013854 chr9 2584 2925 1623 7132 View
5013855 chr9 3056 1081 535 4672 View
5013856 chr9 569 4 5 578 View
5013857 chr9 580 19 15 614 View
5013858 chr9 59 11 9 79 View
5013859 chr9 95 3 0 98 View
5016426 chr9 173 7 0 180 View
5016427 chr9 33 10 1 44 View
5016428 chr9 25 12 4 41 View
5016839 chr9 1027 102 64 1193 View
5016840 chr9 521 10 5 536 View
5016841 chr9 61 12 0 73 View
5016842 chr9 61 12 0 73 View
5016843 chr9 53 18 7 78 View
5016844 chr9 34 169 336 539 View
5016845 chr9 29 153 329 511 View
5016846 chr9 413 8 0 421 View
5016847 chr9 480 18 0 498 View
5016848 chr9 122 14 3 139 View
5016849 chr9 19 0 0 19 View
5016850 chr9 61 4 8 73 View
5016851 chr9 48 19 2 69 View
5016852 chr9 34 23 79 136 View
5016853 chr9 24 6 0 30 View
5016854 chr9 24 6 1 31 View
5017827 chr9 12 0 0 12 View
5017846 chr9 1236 2672 1943 5851 View
5017847 chr9 1200 2581 1926 5707 View
5017848 chr9 2036 402 241 2679 View
5017849 chr9 19 0 0 19 View
5017851 chr9 156 57 77 290 View
5017852 chr9 58 12 0 70 View
5017853 chr9 10 0 0 10 View
5017854 chr9 10 0 0 10 View
5017855 chr9 43 17 2 62 View
5017856 chr9 65 32 6 103 View
5017857 chr9 3 33 3 39 View
5017858 chr9 123 12 44 179 View

Target gene [CD274] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE183048 		Chip-seq 24 Illumina HiSeq 4000 (Homo sapiens)
GSE226620 scRNA-seq 30 HiSeq X Ten (Homo sapiens)
GSE40774 Expression array 134 Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
GSE139324 scRNA-seq 63 Illumina NextSeq 500 (Homo sapiens)
GSE169622 Methylation profiling (Array) 9 Infinium MethylationEPIC
GSE65858 Expression array 270 Illumina HumanHT-12 V4.0 expression beadchip
GSE55550 Expression array 155 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE181805 Expression array 25 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215 RNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
GSE164690 scRNA-seq 51 Illumina NextSeq 500 (Homo sapiens)
GSE138080 Expression array 35 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662 Expression array 8 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542 Expression array 36 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C
  GSE143026 		ATAC-seq;Chip-seq;RNA-seq 30 Illumina HiSeq 2500 (Homo sapiens)
E
  TCGA_CESC 		DNA methylation sequencing;RNA-seq 288 TCGA
GSE51993 Expression array 48 Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE199029 Variation;RNA-seq 44 NanoString Human nCounter PanCancer IO360 Panel
GSE165883 RNA-seq 20 Illumina NextSeq 500 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: TCGA_CESC - CD274 expression across samples

Volcano Plot

Bar Plot