Gene Name	CUL2
Gene ID	8453
Gene Full Name	cullin 2
Gene Alias	-
Transcripts	ENSG00000108094
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;
Membrane Info	Cancer-related genes, Predicted intracellular proteins
Uniport_ID	Q13617
HGNC ID	HGNC:2552
OMIM ID	603135
Summary	Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2025]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5011727	chr10	59	19	3	81	View
5012490	chr10	81	42	3	126	View
5012491	chr10	34	16	12	62	View
5012492	chr10	34	16	12	62	View
5012493	chr10	6	0	0	6	View
5012494	chr10	6	0	0	6	View
5012495	chr10	2	0	0	2	View
5012496	chr10	17	2	0	19	View
5012497	chr10	6	1	0	7	View
5012498	chr10	4	10	0	14	View
5012499	chr10	4	9	0	13	View
5012500	chr10	106	15	10	131	View
5012501	chr10	3427	241	200	3868	View
5012502	chr10	4088	2022	1705	7815	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE40774	Expression array	134	Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE138080	Expression array	35	Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE197461	scRNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens)
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE183048 - CUL2 peak across samples

Peak Plot

> Dataset: GSE143026 - CUL2 peak across samples

Peak Plot