EBV Target gene Detail Information

> DENND2B Gene Search Result


Gene Information
Gene Name DENND2B
Gene ID 6764
Gene Full Name DENN domain containing 2B
Gene Alias HTS1|ST5|p126
Transcripts ENSG00000166444
Virus EBV
Gene Type protein-coding
HPA Location Info Nucleoplasm;
Membrane Info Predicted intracellular proteins
Uniport_ID P78524
HGNC ID HGNC:11350
OMIM ID 140750
Summary This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
Target gene [DENND2B] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
3000275 chr11 41 2 0 43 View

Target gene [DENND2B] related to Omics data
Data ID Experiment type Sample number Platform
GSE42867 Expression array 12 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
C
  GSE246060 		Chip-seq 26 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE198334 		Chip-seq 4 Illumina NextSeq 500 (Homo sapiens)
GSE100458 Expression array 14 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v21]
GSE165194 RNA-seq 3 Illumina NextSeq 500 (Homo sapiens)
C
  GSE246059 		ATAC-seq 8 Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE177046 RNA-seq 6 Illumina HiSeq 2000 (Homo sapiens)
C
  GSE225248 		Chip-seq 12 Illumina NextSeq 500 (Homo sapiens)
GSE102203 Expression array 10 [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [probe set (exon) version]
GSE85599 Expression array 17 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
E
  GSE181906 		RNA-seq 24 Illumina NovaSeq 6000 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE181906 - DENND2B expression across samples

Volcano Plot

Bar Plot