Virus Dataset Detail

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Dataset Information
Accession GSE102203
Status 2018/9/17
Title Expression data from EBV+ and EBV- plasmablastic lymphomas
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We produced and analyzed the transcriptomic profiles of agressive plasmablastic lymphomas to describe their "immune escape" profile, depending on their viral status (HIV, EBV, ...). We used microarrays to compare the global gene expression profile between EBV+ and EBV- PL subtypes. This analysis unveiled the interest of treating EBV+ PL patients by immune checkpoint blockade strategies. Plasmablastic lymphoma (PL) is a subtype of diffuse large B-cell lymphoma occurring frequently in HIV-positive individuals and most often associated with Epstein Barr Virus infection. Despite recent therapeutic progress, PL still is an aggressive lymphoma with adverse prognosis. The aim of this study was to investigate whether the emerging strategies of immune checkpoint blockade could be efficient for PL patients. Here, we produced and analyzed the transcriptomic profiles of such tumors to address this question. Unsupervised hierarchical analysis of PL samples showed that PL segregated according to their EBV-status. Moreover, we report that EBV+ PL displayed a significant association with abundant leucocyte infiltrate and selective T-cell activation signatures, together with high level of inhibitory receptors and immune checkpoint markers. We propose that EBV infection induced an anti-viral cytotoxic immunity which progressively exhausted and promoted the tolerogenic tumor microenvironment of PL. Hence, most EBV+ PL patients presenting an early stage of cancer immune-editing process appear eligible for ICB immunotherapies.
Samples
GSM ID Sample info Characteristics Description
GSM2730278 Patient_10P6274_EBV- tissue:PL biopsy (rhinopharynx); ebv status:EBV- Gene expression data from patient no 10P6274, frozen PL biopsy;1 - 10P6274 EBV-
GSM2730279 Patient_14P5581_EBV+ tissue:PL biopsy (cervical lymph node); ebv status:EBV+ Gene expression data from patient no 14P5581, frozen PL biopsy;2 - 14P5581 EBV+
GSM2730280 Patient_14P11149_EBV+ tissue:PL biopsy (trachea); ebv status:EBV+ Gene expression data from patient no 14P11149, frozen PL biopsy;3 - 14P11149 EBV+
GSM2730281 Patient_12P12002_EBV+ tissue:PL biopsy (kidney); ebv status:EBV+ Gene expression data from patient no 12P12002, frozen PL biopsy;4 - 12P12002 EBV+
GSM2730282 Patient_P14.290_EBV- tissue:PL biopsy (sub mandibulary gland); ebv status:EBV- Gene expression data from patient no P14.290, frozen PL biopsy;5 - P14.290 EBV-
GSM2730283 Patient_14P11667_EBV+ tissue:PL biopsy (nose); ebv status:EBV+ Gene expression data from patient no 14P11667, frozen PL biopsy;6 - 14P11667 EBV+
GSM2730284 Patient_14P11148_EBV- tissue:PL biopsy (sphenoid bone); ebv status:EBV- Gene expression data from patient no 14P11148, frozen PL biopsy;7 - 14P11148 EBV-
GSM2730285 Patient_14T8922_EBV+ tissue:PL biopsy (testis); ebv status:EBV+ Gene expression data from patient no 14T8922, frozen PL biopsy;8 - 14T8922 EBV+
GSM2730286 Patient_14T17450_EBV+ tissue:PL biopsy (sternum); ebv status:EBV+ Gene expression data from patient no 14T17450, frozen PL biopsy;9 - 14T17450 EBV+
GSM2730287 Patient_P11.417_reactionnel tissue:Reactive cervical lymph node Gene expression data from patient no P11.417, frozen lymph node;10 - Temoin P11.417
Platform GPL19251  : [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [probe set (exon) version]
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* p<0.05 ** p<0.01