Virus Dataset Detail

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Dataset Information
Accession GSE85599
Status 2017/12/20
Title Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Epstein–Barr virus (EBV) is a common human pathogen that infects over 95% of the population worldwide. In the present study, the whole transcriptome microarray data were generated from peripheral blood mononuclear cells from Chinese children with acute infectious mononucleosis (AIM) and chronic active EBV infection (CAEBV) that were also compared with a publicly available microarray dataset from a study of American college students with AIM. Our study characterized for the first time a broad spectrum of molecular signatures in AIM and CAEBV. The key findings from the transcriptome profiling were validated with qPCR and flow cytometry assays. The most important finding in our study is the discovery of predominant γδ TCR expression and γδ T cell expansion in AIM. This finding, in combination with the striking up-regulation of CD3, CD8 and CD94, suggests that CD8+ T cells and CD94+ NK cells may play a major role in AIM. Moreover, the unique up-regulation of CD64A/B and its significant correlation with the monocyte marker CD14 was observed in CAEBV and that implies an important role of monocytes in CAEBV. In conclusion, our study reveals major cell types (particularly γδ T cells) in the host cellular immune response against AIM and CAEBV.
Samples
GSM ID Sample info Characteristics Description
GSM2279038 Acute EBV ED490 gender:M; age:12 m; tissue:peripheral blood mononuclear cells; diagnosis:acute infectious mononucleosis (AIM) -
GSM2279022 Acute EBV 15VC1799 gender:M; age:27 m; tissue:peripheral blood mononuclear cells; diagnosis:acute infectious mononucleosis (AIM) -
GSM2279023 Acute EBV 15VC1803 gender:F; age:18 m; tissue:peripheral blood mononuclear cells; diagnosis:acute infectious mononucleosis (AIM) -
GSM2279024 Acute EBV 15VC2293 gender:M; age:4 y; tissue:peripheral blood mononuclear cells; diagnosis:acute infectious mononucleosis (AIM) -
GSM2279025 Chronic EBV 15VC2295 gender:F; age:3 y; tissue:peripheral blood mononuclear cells; diagnosis:chronic active EBV infection (CAEBV) -
GSM2279026 Acute EBV 15VC2386 gender:F; age:3 y; tissue:peripheral blood mononuclear cells; diagnosis:acute infectious mononucleosis (AIM) -
GSM2279027 Chronic EBV 15VC2407 gender:M; age:9 y; tissue:peripheral blood mononuclear cells; diagnosis:chronic active EBV infection (CAEBV) -
GSM2279028 Chronic EBV 15VC2414 gender:M; age:15 y; tissue:peripheral blood mononuclear cells; diagnosis:chronic active EBV infection (CAEBV) -
GSM2279029 Chronic EBV 15VC2656 gender:F; age:2 y; tissue:peripheral blood mononuclear cells; diagnosis:chronic active EBV infection (CAEBV) -
GSM2279030 Chronic EBV 15VC3454 gender:M; age:12 y; tissue:peripheral blood mononuclear cells; diagnosis:chronic active EBV infection (CAEBV) -
GSM2279031 Healthy Control C13 gender:M; age:1 y; tissue:peripheral blood mononuclear cells; diagnosis:healthy -
GSM2279032 Healthy Control C15 gender:F; age:3 y; tissue:peripheral blood mononuclear cells; diagnosis:healthy -
GSM2279033 Healthy Control C21 gender:F; age:1 y; tissue:peripheral blood mononuclear cells; diagnosis:healthy -
GSM2279034 Healthy Control C22 gender:M; age:3 y; tissue:peripheral blood mononuclear cells; diagnosis:healthy -
GSM2279035 Healthy Control C23 gender:M; age:3 y; tissue:peripheral blood mononuclear cells; diagnosis:healthy -
GSM2279036 Healthy Control C24 gender:F; age:4 y; tissue:peripheral blood mononuclear cells; diagnosis:healthy -
GSM2279037 Acute EBV ED483 gender:M; age:24 m; tissue:peripheral blood mononuclear cells; diagnosis:acute infectious mononucleosis (AIM) -
Platform GPL17586  : [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
Literature 29259291  
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