Gene Information
|
Gene Name
|
EGFR |
|
Gene ID
|
1956
|
|
Gene Full Name
|
epidermal growth factor receptor |
|
Gene Alias
|
ERBB|ERBB1|ERRP|HER1|NISBD2|NNCIS|PIG61|mENA |
|
Transcripts
|
ENSG00000146648
|
|
Virus
|
KSHV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Golgi apparatus, Plasma membrane;Nucleoli, Cell Junctions, Primary cilium, Basal body, Cytosol, Mid piece, Principal piece, End piece;Secreted to blood; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins, Transporters |
|
Uniport_ID
|
P00533
|
|
HGNC ID
|
HGNC:3236
|
|
OMIM ID
|
131550 |
|
Summary
|
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020] |
Target gene [EGFR] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [EGFR] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE232843
|
RNA-seq |
12 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE79029
|
RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
C GSE202670
|
Chip-seq |
14 |
Illumina Genome Analyzer (Homo sapiens) |
|
GSE280380
|
RNA-seq |
54 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE158935
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE132777
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
GSE147063
|
Chip-seq;GRO-seq;4C-seq |
10 |
Illumina NextSeq 500 (Homo sapiens);Illumina Hiseq 2500 (Homo sapiens) |
|
GSE207589
|
RNA-seq |
12 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE241095
|
RNA-seq |
44 |
Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE135740
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
C GSE52421
|
Chip-seq |
18 |
Illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE280006
|
RNA-seq |
14 |
NextSeq 550 (Homo sapiens) |
|
C GSE38411
|
Chip-seq |
5 |
Illumina Genome Analyzer II (Homo sapiens);Illumina Genome Analyzer II (Human herpesvirus 8) |
|
GSE260925
|
RNA-seq |
24 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE56144
|
Chip-seq;RNA-seq |
33 |
Illumina Genome Analyzer II (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE202670 - EGFR peak across samples
|
Peak Plot
|
> Dataset: GSE132777 - EGFR peak across samples
|
Peak Plot
|
> Dataset: GSE135740 - EGFR peak across samples
|
Peak Plot
|
> Dataset: GSE52421 - EGFR peak across samples
|
Peak Plot
|
> Dataset: GSE38411 - EGFR peak across samples
|
Peak Plot
|
> Dataset: GSE56144 - EGFR peak across samples
|
Peak Plot
|
|
|
KSHV Target gene Detail Information
