SARS-CoV-2 Target gene Detail Information

> GDF15 Gene Search Result


Gene Information
Gene Name GDF15
Gene ID 9518
Gene Full Name growth differentiation factor 15
Gene Alias GDF-15|HG|MIC-1|MIC1|NAG-1|PDF|PLAB|PTGFB
Transcripts ENSG00000130513
Virus SARS-CoV-2
Gene Type protein-coding
HPA Location Info Golgi apparatus;Secreted to blood;
Membrane Info Cancer-related genes, Disease related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID Q99988
HGNC ID HGNC:30142
OMIM ID 605312
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
Target gene [GDF15] related to virus gene/protein/region

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section


ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 38365933 G28237T
ORF8
ORF8
COVID-19
Cell line
G
R
T
 View

Target gene [GDF15] related to Omics data
Data ID Experiment type Sample number Platform
GSE167075 MeRIP-seq;RNA-seq 16 Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2);Illumina NovaSeq 6000 (Chlorocebus aethiops; Severe acute respiratory syndrome coronavirus 2)
GSE164485 scRNA-seq 36 Illumina HiSeq 2500 (Homo sapiens)
GSE190680 RNA-seq 100 Illumina NovaSeq 6000 (Homo sapiens)
GSE207923 RNA-seq 27 Illumina NovaSeq 6000 (Homo sapiens)
GSE152641 RNA-seq 86 Illumina NovaSeq 6000 (Homo sapiens)
GSE283771 RNA-seq 6 Illumina HiSeq 2000 (Homo sapiens)
GSE211934 RNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
GSE163959 RNA-seq 48 Illumina NextSeq 500 (Homo sapiens)
C
  GSE163623 		Chip-seq 5 Illumina NovaSeq 6000 (Homo sapiens)
GSE166253 RNA-seq 26 HiSeq X Ten (Homo sapiens)
GSE153218 RNA-seq 16 Illumina NextSeq 500 (Homo sapiens)
GSE162323 RNA-seq 42 Illumina NovaSeq 6000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2)
GSE199816 RNA-seq 27 DNBSEQ-G400 (Homo sapiens)
GSE215262 RNA-seq 25 Illumina NovaSeq 6000 (Homo sapiens)


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE163623 - GDF15 peak across samples

Peak Plot