Virus Dataset Detail

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Dataset Information
Accession GSE199816
Status 2022/11/29
Title Transcriptional Differences Between COVID-19 and Sepsis
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Although some studies reported the comprehensive mRNA expression analysis of coronavirus disease 2019 (COVID-19) using blood samples to understand its pathogenesis, the characteristics of RNA expression in COVID-19 and sepsis have not been compared. We compared the transcriptome expression of whole blood samples from patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and patients with sepsis caused by other bacteria who entered the intensive care unit to clarify the COVID-19-specific RNA expression and understand its pathogenesis. Transcriptomes related to mitochondria were upregulated in COVID-19, whereas those related to neutrophils were upregulated in sepsis. However, the transcriptomes related to neutrophils were upregulated in both COVID-19 and sepsis compared to in healthy controls, whereas the mitochondrial transcriptomes were upregulated in COVID-19 and downregulated in sepsis compared to in healthy controls. Moreover, sepsis showed sub-optimal intrinsic apoptotic features compared with COVID-19. The transcriptome expression of COVID-19 has been examined in vitro but has not been widely validated using human specimens. This study improves the understanding of the pathogenesis of COVID-19 and can contribute to the development of treatments.
Samples
GSM ID Sample info Characteristics Description
GSM5987829 COVID-19 patient_COV13 cell type:peripheral blood mononuclear cells; diagnosis:COVID-19 PBMCs derived from COVID-19 patient_COV13
GSM5987830 COVID-19 patient_COV16 cell type:peripheral blood mononuclear cells; diagnosis:COVID-19 PBMCs derived from COVID-19 patient_COV16
GSM5987831 COVID-19 patient_COV20 cell type:peripheral blood mononuclear cells; diagnosis:COVID-19 PBMCs derived from COVID-19 patient_COV20
GSM5987832 COVID-19 patient_COV30 cell type:peripheral blood mononuclear cells; diagnosis:COVID-19 PBMCs derived from COVID-19 patient_COV30
GSM5987833 COVID-19 patient_COV48 cell type:peripheral blood mononuclear cells; diagnosis:COVID-19 PBMCs derived from COVID-19 patient_COV48
GSM5987834 COVID-19 patient_COV84 cell type:peripheral blood mononuclear cells; diagnosis:COVID-19 PBMCs derived from COVID-19 patient_COV84
GSM5987835 COVID-19 patient_COV96 cell type:peripheral blood mononuclear cells; diagnosis:COVID-19 PBMCs derived from COVID-19 patient_COV96
GSM5987836 COVID-19 patient_COV109 cell type:peripheral blood mononuclear cells; diagnosis:COVID-19 PBMCs derived from COVID-19 patient_COV109
GSM5987837 COVID-19 patient_COV111 cell type:peripheral blood mononuclear cells; diagnosis:COVID-19 PBMCs derived from COVID-19 patient_COV111
GSM5987838 SEPSIS patient_P7 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P7
GSM5987839 SEPSIS patient_P9 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P9
GSM5987840 SEPSIS patient_P11 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P11
GSM5987841 SEPSIS patient_P12 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P12
GSM5987842 SEPSIS patient_P14 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P14
GSM5987843 SEPSIS patient_P15 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P15
GSM5987844 SEPSIS patient_P16 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P16
GSM5987845 SEPSIS patient_P17 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P17
GSM5987846 SEPSIS patient_P19 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P19
GSM5987847 SEPSIS patient_P20 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P20
GSM5987848 SEPSIS patient_P21 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P21
GSM5987849 SEPSIS patient_P23 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P23
GSM5987850 SEPSIS patient_P24 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P24
GSM5987851 SEPSIS patient_P25 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P25
GSM5987852 SEPSIS patient_P26 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P26
GSM5987853 SEPSIS patient_P27 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P27
GSM5987854 SEPSIS patient_P28 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P28
GSM5987855 SEPSIS patient_P29 cell type:peripheral blood mononuclear cells; diagnosis:sepsis PBMCs derived from sepsis patient_P29
Platform GPL28038  : DNBSEQ-G400 (Homo sapiens)
Literature 36443881  
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* p<0.05 ** p<0.01