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Dataset Information
| Accession |
GSE211934
|
| Status |
2023/8/24 |
| Title |
Pathological effects of SARS-CoV-2 and α-synuclein preformed fibril in hESC-derived dopaminergic neurons |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing |
| Summary |
Progression Parkinson’s disease (PD) has been strongly correlated to concurrent virus infection such as herpes virus, Helicobacter pylori, hepatitis C, and pneumococcus and the concurrent immune response in the brain. However, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the onset and progression of PD is yet to be investigated. As the pandemic is getting closer to being under control and majority of the population in the world will have been infected with SARS-CoV-2, there will be a huge need for uncovering the unknown, possible neurological sequelae of SARS-CoV-2 infection. Here we report that SARS-CoV-2 infection increased the susceptibility of DA neurons to PFF-induced cell death while PFF or SARS-CoV-2 alone did not exert a cytotoxic effect on dopaminergic (DA) neurons. RNA sequencing data revealed mechanistic investigations that SARS-CoV-2, in vitro, increased susceptibility to PFF-induced PD-like pathology including changes in expression of signaling molecules in apoptosis, autophagy, oxidative stress, and mitochondrial function. Thus, our study provides a previously unappreciated paradigm that SARS-CoV-2 infection persists in the brain and increases susceptibility to neurodegenerative diseases such as PD via continuous inflammatory response as a long-term sequela. |
| Samples |
| GSM ID |
Sample info |
Characteristics |
Description |
|
GSM6505758
|
DAneuron, non-treated, rep1 |
cell line:WA09 hESC; cell type:hESC-derived dopaminergic neuron; genotype:WT; treatment:Dopaminergic neuron differentiation |
- |
|
GSM6505759
|
DAneuron, non-treated, rep2 |
cell line:WA09 hESC; cell type:hESC-derived dopaminergic neuron; genotype:WT; treatment:Dopaminergic neuron differentiation |
- |
|
GSM6505760
|
DAneuron, SARS-CoV-2, rep1 |
cell line:WA09 hESC; cell type:hESC-derived dopaminergic neuron; genotype:WT; treatment:Dopaminergic neuron differentiation, SARS-CoV-2 infection |
- |
|
GSM6505761
|
DAneuron, SARS-CoV-2, rep2 |
cell line:WA09 hESC; cell type:hESC-derived dopaminergic neuron; genotype:WT; treatment:Dopaminergic neuron differentiation, SARS-CoV-2 infection |
- |
|
GSM6505762
|
DAneuron, PFF, rep1 |
cell line:WA09 hESC; cell type:hESC-derived dopaminergic neuron; genotype:WT; treatment:Dopaminergic neuron differentiation, a-synuclein preformed fibril |
- |
|
GSM6505763
|
DAneuron, PFF, rep2 |
cell line:WA09 hESC; cell type:hESC-derived dopaminergic neuron; genotype:WT; treatment:Dopaminergic neuron differentiation, a-synuclein preformed fibril |
- |
|
GSM6505764
|
DAneuron, PFF and SARS-CoV-2, rep1 |
cell line:WA09 hESC; cell type:hESC-derived dopaminergic neuron; genotype:WT; treatment:Dopaminergic neuron differentiation, a-synuclein preformed fibril, SARS-CoV-2 infection |
- |
|
GSM6505765
|
DAneuron, PFF and SARS-CoV-2, rep2 |
cell line:WA09 hESC; cell type:hESC-derived dopaminergic neuron; genotype:WT; treatment:Dopaminergic neuron differentiation, a-synuclein preformed fibril, SARS-CoV-2 infection |
- |
|
| Platform |
GPL24676 : Illumina NovaSeq 6000 (Homo sapiens) |
| Literature |
38749422 |
| Download |
Download xCell Data Download Expression Analysis Data
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xCell Plot
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* p<0.05 ** p<0.01
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Virus Dataset Detail
