Virus Dataset Detail

> Detail information for each sample

Dataset Information
Accession GSE215262
Status 2023/6/10
Title Transcriptional patterns of peripheral blood mononuclear cells (PBMCs) in SARS-CoV-2 infected patients with different severity and outcome
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological pathogen of coronavirus disease 2019 (COVID-19), a highly contagious disease, spreading quickly and threatening global public health. The symptoms of the disease vary from mild reactions to severe respiratory distress or even fatal outcomes probably due to the different status of innate immunity which is the first line to combat the virus. Here in the study, we unveiled the underlying transcriptional patterns of peripheral blood mononuclear cells (PBMCs) using SARS-CoV-2 infected patients with different severity and outcome. Through systemic analysis, an anti-microbe peptide, α-defensin-1 (DEFA1) was identified to be elevated in both plasma and PBMCs in COVID19 patients, and the function and mechanism is studied.
Samples
GSM ID Sample info Characteristics Description
GSM6630576 Normal-3 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630577 Normal-4 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630578 Normal-5 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630579 Normal-6 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630580 Normal-7 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630581 Normal-8 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630582 Normal-9 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630558 P5-rep1 H5 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630559 P5-rep4 L3 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630560 P1-rep0 L4 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630561 P5-rep5 L8 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630562 P5-rep5 LD10 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630563 P3-rep0 LD13 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630564 P9-rep3 LD14 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630565 P10-rep1 LD2 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630566 P9-rep0 LD8 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630567 P9-rep2 LD9 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630568 Normal-1 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630569 Normal-10 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630570 Normal-11 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630571 Normal-12 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630572 Normal-13 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630573 Normal-14 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630574 Normal-15 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
GSM6630575 Normal-2 cell type:peripheral blood mononuclear cells; cell line:primary cell; tissue:blood -
Platform GPL24676  : Illumina NovaSeq 6000 (Homo sapiens)
Literature 37254949  
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xCell Plot
* p<0.05 ** p<0.01