Virus Dataset Detail

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Dataset Information
Accession GSE283771
Status 2024/12/15
Title Effects of SARS-CoV-2 S protein on endothelial cell thrombosis
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The outbreak of Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, has led to an unparalleled global health crisis. While the majority of COVID-19 patients present with mild respiratory issues, a subset of patients still develop severe symptoms and life-threatening complications. Notably, abnormal coagulation and thrombosis are significant contributors to mortality in severe COVID-19 patients. Therefore, this study stimulated aortic endothelial cells with SARS-Cov-2 S protein and performed transcriptome sequencing analysis.
Samples
GSM ID Sample info Characteristics Description
GSM8671883 Untreated HAEC cells 1 tissue:cell line; cell line:HAEC; cell type:Human amniotic epithelial cells; genotype:WT; treatment:Unprocessed Library name: hc1
GSM8671884 Untreated HAEC cells 2 tissue:cell line; cell line:HAEC; cell type:Human amniotic epithelial cells; genotype:WT; treatment:Unprocessed Library name: hc2
GSM8671885 Untreated HAEC cells 3 tissue:cell line; cell line:HAEC; cell type:Human amniotic epithelial cells; genotype:WT; treatment:Unprocessed Library name: hc3
GSM8671886 SARS-Cov-2 S protein treatment of HAEC cells 1 tissue:cell line; cell line:HAEC; cell type:Human amniotic epithelial cells; genotype:S; treatment:10NM SARS-CoV-2 S protein stimulation Library name: s1
GSM8671887 SARS-Cov-2 S protein treatment of HAEC cells 2 tissue:cell line; cell line:HAEC; cell type:Human amniotic epithelial cells; genotype:S; treatment:10NM SARS-CoV-2 S protein stimulation Library name: s2
GSM8671888 SARS-Cov-2 S protein treatment of HAEC cells 3 tissue:cell line; cell line:HAEC; cell type:Human amniotic epithelial cells; genotype:S; treatment:10NM SARS-CoV-2 S protein stimulation Library name: s3
Platform GPL11154  : Illumina HiSeq 2000 (Homo sapiens)
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* p<0.05 ** p<0.01