Gene Name	HLA-A
Gene ID	3105
Gene Full Name	major histocompatibility complex, class I, A
Gene Alias	HLAA
Transcripts	ENSG00000206503
Virus	SARS-CoV-2
Gene Type	protein-coding
HPA Location Info	Plasma membrane;Golgi apparatus;
Membrane Info	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P04439
HGNC ID	HGNC:4931
OMIM ID	142800
Summary	HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	38397027	H47Y	ORF7a	ORF7a		G R S T	View

Data ID	Experiment type	Sample number	Platform
GSE167075	MeRIP-seq;RNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2);Illumina NovaSeq 6000 (Chlorocebus aethiops; Severe acute respiratory syndrome coronavirus 2)
GSE164485	scRNA-seq	36	Illumina HiSeq 2500 (Homo sapiens)
GSE190680	RNA-seq	100	Illumina NovaSeq 6000 (Homo sapiens)
GSE152641	RNA-seq	86	Illumina NovaSeq 6000 (Homo sapiens)
GSE283771	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
GSE211934	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE163959	RNA-seq	48	Illumina NextSeq 500 (Homo sapiens)
S   GSE206147	scRNA-seq	1	Illumina NovaSeq 6000 (Homo sapiens)
GSE240694	scRNA-seq	9	Illumina NovaSeq 6000 (Homo sapiens)
GSE166253	RNA-seq	26	HiSeq X Ten (Homo sapiens)
GSE153218	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)
GSE162323	RNA-seq	42	Illumina NovaSeq 6000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2)
GSE199816	RNA-seq	27	DNBSEQ-G400 (Homo sapiens)
GSE215262	RNA-seq	25	Illumina NovaSeq 6000 (Homo sapiens)

• scRNA data

When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.

> Dataset: GSE206147 - Gene expression in cell subsets