Gene Name	IFNB1
Gene ID	3456
Gene Full Name	interferon beta 1
Gene Alias	IFB|IFF|IFN-beta|IFNB
Transcripts	ENSG00000171855
Virus	SARS-CoV-2
Gene Type	protein-coding
HPA Location Info	Secreted to blood;
Membrane Info	Cancer-related genes, Predicted secreted proteins
Uniport_ID	P01574
HGNC ID	HGNC:5434
OMIM ID	147640
Summary	This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	38397027	H47Y	ORF7a	ORF7a		G R S T	View

Data ID	Experiment type	Sample number	Platform
GSE167075	MeRIP-seq;RNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2);Illumina NovaSeq 6000 (Chlorocebus aethiops; Severe acute respiratory syndrome coronavirus 2)
GSE190680	RNA-seq	100	Illumina NovaSeq 6000 (Homo sapiens)
GSE207923	RNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE152641	RNA-seq	86	Illumina NovaSeq 6000 (Homo sapiens)
GSE283771	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
GSE211934	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE163959	RNA-seq	48	Illumina NextSeq 500 (Homo sapiens)
C   GSE163623	Chip-seq	5	Illumina NovaSeq 6000 (Homo sapiens)
GSE166253	RNA-seq	26	HiSeq X Ten (Homo sapiens)
GSE153218	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)
E   GSE162323	RNA-seq	42	Illumina NovaSeq 6000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2)
GSE199816	RNA-seq	27	DNBSEQ-G400 (Homo sapiens)
GSE215262	RNA-seq	25	Illumina NovaSeq 6000 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE162323 - IFNB1 expression across samples

Volcano Plot

Bar Plot