Gene Information
|
Gene Name
|
IL1B |
|
Gene ID
|
3553
|
|
Gene Full Name
|
interleukin 1 beta |
|
Gene Alias
|
IL-1|IL1-BETA|IL1F2|IL1beta |
|
Transcripts
|
ENSG00000125538
|
|
Virus
|
KSHV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Secreted to blood; 
|
|
Membrane Info
|
Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters |
|
Uniport_ID
|
P01584
|
|
HGNC ID
|
HGNC:5992
|
|
OMIM ID
|
147720 |
|
Summary
|
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] |
Target gene [IL1B] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [IL1B] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE232843
|
RNA-seq |
12 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE79029
|
RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
C GSE202670
|
Chip-seq |
14 |
Illumina Genome Analyzer (Homo sapiens) |
|
GSE280380
|
RNA-seq |
54 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE158935
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE132777
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
GSE147063
|
Chip-seq;GRO-seq;4C-seq |
10 |
Illumina NextSeq 500 (Homo sapiens);Illumina Hiseq 2500 (Homo sapiens) |
|
GSE207589
|
RNA-seq |
12 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE241095
|
RNA-seq |
44 |
Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE135740
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
C GSE52421
|
Chip-seq |
18 |
Illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE280006
|
RNA-seq |
14 |
NextSeq 550 (Homo sapiens) |
|
C GSE38411
|
Chip-seq |
5 |
Illumina Genome Analyzer II (Homo sapiens);Illumina Genome Analyzer II (Human herpesvirus 8) |
|
GSE260925
|
RNA-seq |
24 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE56144
|
Chip-seq;RNA-seq |
33 |
Illumina Genome Analyzer II (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE202670 - IL1B peak across samples
|
Peak Plot
|
> Dataset: GSE132777 - IL1B peak across samples
|
Peak Plot
|
> Dataset: GSE135740 - IL1B peak across samples
|
Peak Plot
|
> Dataset: GSE52421 - IL1B peak across samples
|
Peak Plot
|
> Dataset: GSE38411 - IL1B peak across samples
|
Peak Plot
|
> Dataset: GSE56144 - IL1B peak across samples
|
Peak Plot
|
|
|
KSHV Target gene Detail Information
