Gene Information
|
Gene Name
|
NFKB1 |
|
Gene ID
|
4790
|
|
Gene Full Name
|
nuclear factor kappa B subunit 1 |
|
Gene Alias
|
CVID12|EBP-1|KBF1|NF-kB|NF-kB1|NF-kappa-B1|NF-kappaB|NF-kappabeta|NFKB-p105|NFKB-p50|NFkappaB |
|
Transcripts
|
ENSG00000109320
|
|
Virus
|
KSHV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Cytosol; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors |
|
Uniport_ID
|
P19838
|
|
HGNC ID
|
HGNC:7794
|
|
OMIM ID
|
164011 |
|
Summary
|
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020] |
Target gene [NFKB1] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
| ID |
PMID |
Mutation |
Gene/Protein/Region |
Encoding Gene/Protein |
Disease |
Description |
Detail |
| 1 |
23804715 |
A57L |
vFLIP
|
HHV8GK18_gp80
|
Cell line
|
T
|
View |
Target gene [NFKB1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE232843
|
RNA-seq |
12 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE79029
|
RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
C GSE202670
|
Chip-seq |
14 |
Illumina Genome Analyzer (Homo sapiens) |
|
GSE280380
|
RNA-seq |
54 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE158935
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE132777
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
GSE147063
|
Chip-seq;GRO-seq;4C-seq |
10 |
Illumina NextSeq 500 (Homo sapiens);Illumina Hiseq 2500 (Homo sapiens) |
|
GSE207589
|
RNA-seq |
12 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE241095
|
RNA-seq |
44 |
Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE135740
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
C GSE52421
|
Chip-seq |
18 |
Illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE280006
|
RNA-seq |
14 |
NextSeq 550 (Homo sapiens) |
|
C GSE38411
|
Chip-seq |
5 |
Illumina Genome Analyzer II (Homo sapiens);Illumina Genome Analyzer II (Human herpesvirus 8) |
|
GSE260925
|
RNA-seq |
24 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE56144
|
Chip-seq;RNA-seq |
33 |
Illumina Genome Analyzer II (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE202670 - NFKB1 peak across samples
|
Peak Plot
|
> Dataset: GSE132777 - NFKB1 peak across samples
|
Peak Plot
|
> Dataset: GSE135740 - NFKB1 peak across samples
|
Peak Plot
|
> Dataset: GSE52421 - NFKB1 peak across samples
|
Peak Plot
|
> Dataset: GSE38411 - NFKB1 peak across samples
|
Peak Plot
|
> Dataset: GSE56144 - NFKB1 peak across samples
|
Peak Plot
|
|
|
KSHV Target gene Detail Information
