Gene Information
|
Gene Name
|
PLAT |
|
Gene ID
|
5327
|
|
Gene Full Name
|
plasminogen activator, tissue type |
|
Gene Alias
|
T-PA|TPA |
|
Transcripts
|
ENSG00000104368
|
|
Virus
|
SARS-CoV-2 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Actin filaments;Secreted to blood; 
|
|
Membrane Info
|
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins |
|
Uniport_ID
|
P00750
|
|
HGNC ID
|
HGNC:9051
|
|
OMIM ID
|
173370 |
|
Summary
|
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
Target gene [PLAT] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [PLAT] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE167075
|
MeRIP-seq;RNA-seq |
16 |
Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2);Illumina NovaSeq 6000 (Chlorocebus aethiops; Severe acute respiratory syndrome coronavirus 2) |
|
GSE164485
|
scRNA-seq |
36 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE190680
|
RNA-seq |
100 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE207923
|
RNA-seq |
27 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE152641
|
RNA-seq |
86 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE283771
|
RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE211934
|
RNA-seq |
8 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE163959
|
RNA-seq |
48 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE166253
|
RNA-seq |
26 |
HiSeq X Ten (Homo sapiens) |
|
GSE153218
|
RNA-seq |
16 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE162323
|
RNA-seq |
42 |
Illumina NovaSeq 6000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2) |
|
GSE199816
|
RNA-seq |
27 |
DNBSEQ-G400 (Homo sapiens) |
|
GSE215262
|
RNA-seq |
25 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
|
SARS-CoV-2 Target gene Detail Information
