Gene Name	PLD3
Gene ID	23646
Gene Full Name	phospholipase D family member 3
Gene Alias	AD19|HU-K4|HUK4|SCA46
Transcripts	ENSG00000105223
Virus	SARS-CoV-2
Gene Type	protein-coding
HPA Location Info	Endoplasmic reticulum, Cytosol;Nucleoplasm;
Membrane Info	Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q8IV08
HGNC ID	HGNC:17158
OMIM ID	615698
Summary	This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	38365933	G28237T	ORF8	ORF8	COVID-19 Cell line	G R T	View

Data ID	Experiment type	Sample number	Platform
GSE167075	MeRIP-seq;RNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2);Illumina NovaSeq 6000 (Chlorocebus aethiops; Severe acute respiratory syndrome coronavirus 2)
GSE164485	scRNA-seq	36	Illumina HiSeq 2500 (Homo sapiens)
GSE190680	RNA-seq	100	Illumina NovaSeq 6000 (Homo sapiens)
GSE207923	RNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE152641	RNA-seq	86	Illumina NovaSeq 6000 (Homo sapiens)
GSE283771	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
GSE211934	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE163959	RNA-seq	48	Illumina NextSeq 500 (Homo sapiens)
S   GSE206147	scRNA-seq	1	Illumina NovaSeq 6000 (Homo sapiens)
GSE240694	scRNA-seq	9	Illumina NovaSeq 6000 (Homo sapiens)
GSE166253	RNA-seq	26	HiSeq X Ten (Homo sapiens)
GSE153218	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)
GSE162323	RNA-seq	42	Illumina NovaSeq 6000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2)
E   GSE199816	RNA-seq	27	DNBSEQ-G400 (Homo sapiens)
GSE215262	RNA-seq	25	Illumina NovaSeq 6000 (Homo sapiens)

• Expression profiling
• scRNA data

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE199816 - PLD3 expression across samples

Volcano Plot

Bar Plot