SARS-CoV-2 Target gene Detail Information

> PLOD2 Gene Search Result


Gene Information
Gene Name PLOD2
Gene ID 5352
Gene Full Name procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Gene Alias BRKS2|LH2|TLH
Transcripts ENSG00000152952
Virus SARS-CoV-2
Gene Type protein-coding
HPA Location Info Nucleoli, Cytosol;Intracellular and membrane;
Membrane Info Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID O00469
HGNC ID HGNC:9082
OMIM ID 601865
Summary The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Target gene [PLOD2] related to virus gene/protein/region

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section


ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 38365933 G28237T
ORF8
ORF8
COVID-19
Cell line
G
R
T
 View

Target gene [PLOD2] related to Omics data
Data ID Experiment type Sample number Platform
E
  GSE167075 		MeRIP-seq;RNA-seq 16 Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2);Illumina NovaSeq 6000 (Chlorocebus aethiops; Severe acute respiratory syndrome coronavirus 2)
GSE164485 scRNA-seq 36 Illumina HiSeq 2500 (Homo sapiens)
GSE190680 RNA-seq 100 Illumina NovaSeq 6000 (Homo sapiens)
GSE207923 RNA-seq 27 Illumina NovaSeq 6000 (Homo sapiens)
GSE152641 RNA-seq 86 Illumina NovaSeq 6000 (Homo sapiens)
GSE283771 RNA-seq 6 Illumina HiSeq 2000 (Homo sapiens)
GSE211934 RNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
GSE163959 RNA-seq 48 Illumina NextSeq 500 (Homo sapiens)
GSE206147 scRNA-seq 1 Illumina NovaSeq 6000 (Homo sapiens)
C
  GSE163623 		Chip-seq 5 Illumina NovaSeq 6000 (Homo sapiens)
GSE166253 RNA-seq 26 HiSeq X Ten (Homo sapiens)
GSE153218 RNA-seq 16 Illumina NextSeq 500 (Homo sapiens)
GSE162323 RNA-seq 42 Illumina NovaSeq 6000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2)
GSE199816 RNA-seq 27 DNBSEQ-G400 (Homo sapiens)
GSE215262 RNA-seq 25 Illumina NovaSeq 6000 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE167075 - PLOD2 expression across samples

Volcano Plot

Bar Plot