Gene Name	PTPN3
Gene ID	5774
Gene Full Name	protein tyrosine phosphatase non-receptor type 3
Gene Alias	PTP-H1|PTPH1
Transcripts	ENSG00000070159
Virus	HPV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P26045
HGNC ID	HGNC:9655
OMIM ID	176877
Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	30875834	K64A	E6	E6	Skin Neoplasms	G T	View
2	30875834	L61A	E6	E6	Skin Neoplasms	G T	View
3	30875834	P38A	E6	E6	Skin Neoplasms	G T	View
4	30875834	V68A	E6	E6	Skin Neoplasms	G T	View
5	30875834	W63A	E6	E6	Skin Neoplasms	G T	View

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5016487	chr9	3	3	0	6	View
5016488	chr9	26	10	2	38	View
5016489	chr9	205	57	9	271	View
5016490	chr9	218	98	40	356	View
5016491	chr9	147	27	1	175	View
5016492	chr9	46	9	1	56	View
5016493	chr9	27	6	33	66	View
5016494	chr9	12	2	1	15	View
5016495	chr9	13	4	1	18	View
5016496	chr9	8	0	0	8	View
5016497	chr9	24	0	0	24	View
5016498	chr9	9	0	0	9	View
5016499	chr9	9	0	0	9	View
5016500	chr9	414	161	40	615	View
5016501	chr9	6	2	0	8	View
5016502	chr9	12	0	0	12	View
5016503	chr9	545	89	41	675	View
5016504	chr9	16	2	0	18	View
5016505	chr9	18	2	0	20	View
5016506	chr9	510	29	3	542	View
5016507	chr9	465	15	4	484	View
5016508	chr9	380	39	11	430	View
5016509	chr9	274	88	62	424	View
5016510	chr9	205	2	1	208	View
5016511	chr9	20	1	0	21	View
5016512	chr9	113	90	53	256	View
5016513	chr9	6	4	32	42	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE40774	Expression array	134	Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE164690	scRNA-seq	51	Illumina NextSeq 500 (Homo sapiens)
GSE138080	Expression array	35	Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE197461	scRNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens)
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE183048 - PTPN3 peak across samples

Peak Plot

> Dataset: GSE143026 - PTPN3 peak across samples

Peak Plot