Gene Name	RASAL1
Gene ID	8437
Gene Full Name	RAS protein activator like 1
Gene Alias	RASAL
Transcripts	ENSG00000111344
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Plasma membrane, Cytosol;Cell Junctions;
Membrane Info	Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	O95294
HGNC ID	HGNC:9873
OMIM ID	604118
Summary	The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5012633	chr12	48	29	3	80	View
5012634	chr12	47	26	3	76	View
5012635	chr12	4	2	0	6	View
5012636	chr12	4	2	0	6	View
5012637	chr12	26	12	1	39	View
5012638	chr12	6	10	0	16	View
5012639	chr12	952	511	529	1992	View
5012640	chr12	1201	508	368	2077	View
5012641	chr12	848	330	200	1378	View
5012642	chr12	833	323	195	1351	View
5012643	chr12	47	0	0	47	View
5012644	chr12	27	5	1	33	View
5012645	chr12	1	1	0	2	View
5012646	chr12	111	59	19	189	View
5012647	chr12	108	49	24	181	View
5012648	chr12	95	42	21	158	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE40774	Expression array	134	Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE138080	Expression array	35	Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
E   TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE199029	Variation;RNA-seq	44	NanoString Human nCounter PanCancer IO360 Panel
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: TCGA_CESC - RASAL1 expression across samples

Volcano Plot

Bar Plot