Gene Name	RSAD2
Gene ID	91543
Gene Full Name	radical S-adenosyl methionine domain containing 2
Gene Alias	SAND|cig33|cig5|vig1
Transcripts	ENSG00000134321
Virus	KSHV
Gene Type	protein-coding
HPA Location Info	Nucleoli fibrillar center, Endoplasmic reticulum;
Membrane Info	Predicted intracellular proteins
Uniport_ID	Q8WXG1
HGNC ID	HGNC:30908
OMIM ID	607810
Summary	The protein encoded by this gene is an interferon-inducible antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes. The protein plays a role in cellular antiviral response and innate immune signaling. Antiviral effects result from inhibition of viral RNA replication, interference in the secretory pathway, binding to viral proteins and dysregulation of cellular lipid metabolism. The protein has been found to inhibit both DNA and RNA viruses, including influenza virus, human immunodeficiency virus (HIV-1) and Zika virus. [provided by RefSeq, Sep 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	23804715	A57L	vFLIP	HHV8GK18_gp80	Cell line	T	View

Data ID	Experiment type	Sample number	Platform
GSE232843	RNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE79029	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE202670	Chip-seq	14	Illumina Genome Analyzer (Homo sapiens)
GSE280380	RNA-seq	54	Illumina NovaSeq 6000 (Homo sapiens)
GSE158935	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE132777	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE207589	RNA-seq	12	Illumina HiSeq 2000 (Homo sapiens)
GSE241095	RNA-seq	44	Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE135740	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
C   GSE52421	Chip-seq	18	Illumina Genome Analyzer IIx (Homo sapiens)
GSE280006	RNA-seq	14	NextSeq 550 (Homo sapiens)
C   GSE38411	Chip-seq	5	Illumina Genome Analyzer II (Homo sapiens);Illumina Genome Analyzer II (Human herpesvirus 8)
GSE260925	RNA-seq	24	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE56144	Chip-seq;RNA-seq	33	Illumina Genome Analyzer II (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE202670 - RSAD2 peak across samples

Peak Plot

> Dataset: GSE132777 - RSAD2 peak across samples

Peak Plot

> Dataset: GSE135740 - RSAD2 peak across samples

Peak Plot

> Dataset: GSE52421 - RSAD2 peak across samples

Peak Plot

> Dataset: GSE38411 - RSAD2 peak across samples

Peak Plot

> Dataset: GSE56144 - RSAD2 peak across samples

Peak Plot