Gene Name	SUMO1
Gene ID	7341
Gene Full Name	small ubiquitin like modifier 1
Gene Alias	DAP1|GMP1|OFC10|PIC1|SENP2|SMT3|SMT3C|SMT3H3|UBL1
Transcripts	ENSG00000116030
Virus	KSHV
Gene Type	protein-coding
HPA Location Info	Nuclear membrane, Nuclear bodies;Nucleoplasm, Nucleoli;
Membrane Info	Disease related genes, Human disease related genes, Predicted intracellular proteins
Uniport_ID	P63165
HGNC ID	HGNC:12502
OMIM ID	601912
Summary	This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	23990779	H145L	RTA	ORF50	Cell line	R T	View

Data ID	Experiment type	Sample number	Platform
GSE232843	RNA-seq	12	Illumina NovaSeq 6000 (Homo sapiens)
GSE79029	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE202670	Chip-seq	14	Illumina Genome Analyzer (Homo sapiens)
GSE280380	RNA-seq	54	Illumina NovaSeq 6000 (Homo sapiens)
GSE158935	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE132777	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE147063	Chip-seq;GRO-seq;4C-seq	10	Illumina NextSeq 500 (Homo sapiens);Illumina Hiseq 2500 (Homo sapiens)
GSE207589	RNA-seq	12	Illumina HiSeq 2000 (Homo sapiens)
GSE241095	RNA-seq	44	Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
C   GSE135740	Chip-seq	10	Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
C   GSE52421	Chip-seq	18	Illumina Genome Analyzer IIx (Homo sapiens)
GSE280006	RNA-seq	14	NextSeq 550 (Homo sapiens)
C   GSE38411	Chip-seq	5	Illumina Genome Analyzer II (Homo sapiens);Illumina Genome Analyzer II (Human herpesvirus 8)
GSE260925	RNA-seq	24	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE56144	Chip-seq;RNA-seq	33	Illumina Genome Analyzer II (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE202670 - SUMO1 peak across samples

Peak Plot

> Dataset: GSE132777 - SUMO1 peak across samples

Peak Plot

> Dataset: GSE135740 - SUMO1 peak across samples

Peak Plot

> Dataset: GSE52421 - SUMO1 peak across samples

Peak Plot

> Dataset: GSE38411 - SUMO1 peak across samples

Peak Plot

> Dataset: GSE56144 - SUMO1 peak across samples

Peak Plot