Gene Name	TBK1
Gene ID	29110
Gene Full Name	TANK binding kinase 1
Gene Alias	AIARV|FTDALS4|IIAE8|NAK|T2K
Transcripts	ENSG00000183735
Virus	SARS-CoV-2
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Vesicles;
Membrane Info	Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	Q9UHD2
HGNC ID	HGNC:11584
OMIM ID	604834
Summary	The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	38293247	F35G	NSP6	ORF1a		R I T	View
2	38293247	I162T	NSP6	ORF1a		R I T	View
3	38293247	L125F	NSP6	ORF1a		R I T	View
4	38293247	L37F	NSP6	ORF1a		R I T	View

Data ID	Experiment type	Sample number	Platform
GSE167075	MeRIP-seq;RNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2);Illumina NovaSeq 6000 (Chlorocebus aethiops; Severe acute respiratory syndrome coronavirus 2)
GSE164485	scRNA-seq	36	Illumina HiSeq 2500 (Homo sapiens)
GSE190680	RNA-seq	100	Illumina NovaSeq 6000 (Homo sapiens)
GSE207923	RNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE152641	RNA-seq	86	Illumina NovaSeq 6000 (Homo sapiens)
GSE283771	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
GSE211934	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE163959	RNA-seq	48	Illumina NextSeq 500 (Homo sapiens)
C   GSE163623	Chip-seq	5	Illumina NovaSeq 6000 (Homo sapiens)
GSE240694	scRNA-seq	9	Illumina NovaSeq 6000 (Homo sapiens)
GSE166253	RNA-seq	26	HiSeq X Ten (Homo sapiens)
GSE153218	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)
GSE162323	RNA-seq	42	Illumina NovaSeq 6000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2)
GSE199816	RNA-seq	27	DNBSEQ-G400 (Homo sapiens)
E   GSE215262	RNA-seq	25	Illumina NovaSeq 6000 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE215262 - TBK1 expression across samples

Volcano Plot

Bar Plot