Gene Information
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Gene Name
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TMPRSS2 |
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Gene ID
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7113
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Gene Full Name
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transmembrane serine protease 2 |
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Gene Alias
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PRSS10 |
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Transcripts
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ENSG00000184012
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Virus
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SARS-CoV-2 |
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Gene Type
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protein-coding |
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HPA Location Info
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Plasma membrane;Secreted in other tissues; 
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Membrane Info
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Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
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Uniport_ID
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O15393
|
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HGNC ID
|
HGNC:11876
|
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OMIM ID
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602060 |
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Summary
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This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020] |
Target gene [TMPRSS2] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
| ID |
PMID |
Mutation |
Gene/Protein/Region |
Encoding Gene/Protein |
Disease |
Description |
Detail |
| 1 |
40020261 |
D614G |
RBD
|
S
|
COVID-19
|
L
T
|
View |
Target gene [TMPRSS2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE167075
|
MeRIP-seq;RNA-seq |
16 |
Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2);Illumina NovaSeq 6000 (Chlorocebus aethiops; Severe acute respiratory syndrome coronavirus 2) |
|
GSE190680
|
RNA-seq |
100 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE207923
|
RNA-seq |
27 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE152641
|
RNA-seq |
86 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE283771
|
RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE211934
|
RNA-seq |
8 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE163959
|
RNA-seq |
48 |
Illumina NextSeq 500 (Homo sapiens) |
|
S GSE206147
|
scRNA-seq |
1 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE163623
|
Chip-seq |
5 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE166253
|
RNA-seq |
26 |
HiSeq X Ten (Homo sapiens) |
|
GSE153218
|
RNA-seq |
16 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE162323
|
RNA-seq |
42 |
Illumina NovaSeq 6000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2) |
|
GSE199816
|
RNA-seq |
27 |
DNBSEQ-G400 (Homo sapiens) |
|
GSE215262
|
RNA-seq |
25 |
Illumina NovaSeq 6000 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.
> Dataset: GSE206147 - Gene expression in cell subsets
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SARS-CoV-2 Target gene Detail Information
