Gene Name	ZDHHC5
Gene ID	25921
Gene Full Name	zDHHC palmitoyltransferase 5
Gene Alias	DHHC5|ZNF375
Transcripts	ENSG00000156599
Virus	SARS-CoV-2
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Plasma membrane;
Membrane Info	Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q9C0B5
HGNC ID	HGNC:18472
OMIM ID	614586
Summary	Enables protein-cysteine S-palmitoyltransferase activity. Involved in positive regulation of defense response; positive regulation of protein localization to plasma membrane; and protein localization to plasma membrane. Acts upstream of or within protein palmitoylation. Located in nucleoplasm; phagocytic vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	38365933	C22674T	S	S	COVID-19 Cell line	G R T	View
2	38365933	E1182G	S	S	COVID-19 Cell line	R T	View
3	38365933	A25107G	S	S	COVID-19 Cell line	R T	View
4	38365933	S371F	S	S	COVID-19 Cell line	R T	View

Data ID	Experiment type	Sample number	Platform
E   GSE167075	MeRIP-seq;RNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2);Illumina NovaSeq 6000 (Chlorocebus aethiops; Severe acute respiratory syndrome coronavirus 2)
GSE190680	RNA-seq	100	Illumina NovaSeq 6000 (Homo sapiens)
GSE207923	RNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE152641	RNA-seq	86	Illumina NovaSeq 6000 (Homo sapiens)
GSE283771	RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
GSE211934	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE163959	RNA-seq	48	Illumina NextSeq 500 (Homo sapiens)
GSE206147	scRNA-seq	1	Illumina NovaSeq 6000 (Homo sapiens)
GSE166253	RNA-seq	26	HiSeq X Ten (Homo sapiens)
GSE153218	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)
GSE162323	RNA-seq	42	Illumina NovaSeq 6000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens; Severe acute respiratory syndrome coronavirus 2)
GSE199816	RNA-seq	27	DNBSEQ-G400 (Homo sapiens)
GSE215262	RNA-seq	25	Illumina NovaSeq 6000 (Homo sapiens)

• Expression profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE167075 - ZDHHC5 expression across samples

Volcano Plot

Bar Plot