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Virus Gene/Protein ORF1a ORF1b ORF3a S E M N ORF7a ORF7b ORF8 ORF1ab ORF9b ORF10 ORF6 ORF9c

Disease COVID-19 Cell line Cystic Fibrosis Pediatric Multisystem Inflammatory Disease, COVID-19 related Thrombosis, COVID-19 related HIV Infections

Description Genotype/Subtype Immune Target gene Clinical data Treatment Location Sequence data

For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a

  

ORF1b

  

ORF3a

  

3CLpro

  

3'UTR

  

5'UTR

  

RBD

  

ORF7b-ORF8

  

upstream of N

  

Furin cleavage site

  

E

  

endoRNase

  

Exonuclease

  

S

  

NSP13

  

NSP3

  

M

  

Mpro

  

Methyltransferase

  

N

  

NSP14

  

NSP12

  

Non-coding region

  

NP

  

NS3

  

NS7a

  

NS7b

  

NS8

  

NSP5

  

NSP1

  

NSP10

  

NSP11

  

NSP15

  

NSP16

  

NSP2

  

NSP4

  

NSP6

  

NSP7

  

NSP8

  

NSP9

  

NTD

  

ORF8

  

ORF1ab

  

ORF9b

  

ORF10

  

ORF3

  

ORF6

  

ORF7a

  

ORF7b

  

ORF9

  

ORF9c

  

PLpro

  

RdRp

  

RBM

  

Replicase

  

RNA primase

  

• Mutation
• Sequence

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	39675720	C145A	Mpro	ORF1a	Cell line		View
2	35380892	H41A	Mpro	ORF1a	Cell line		View
3	39259728	A193P	Mpro	ORF1a	Cell line		View
4	39259728	A194S	Mpro	ORF1a	Cell line		View
5	39259728	A206T	Mpro	ORF1a	Cell line	D	View
6	39259728	A210S	Mpro	ORF1a	Cell line		View
7	39259728	A234T	Mpro	ORF1a	Cell line		View
8	39259728	A266T	Mpro	ORF1a	Cell line		View
9	39259728	C145A	Mpro	ORF1a	Cell line		View
10	39259728	E166V	Mpro	ORF1a	Cell line		View
11	39259728	F305L	Mpro	ORF1a	Cell line	D	View
12	39259728	F8L	Mpro	ORF1a	Cell line	D	View
13	39259728	K100N	Mpro	ORF1a	Cell line	D	View
14	39259728	L167F	Mpro	ORF1a	Cell line	D	View
15	39259728	L57F	Mpro	ORF1a	Cell line	D	View
16	39259728	P168S	Mpro	ORF1a	Cell line	D	View
17	39259728	P184S	Mpro	ORF1a	Cell line	D	View
18	39259728	R188W	Mpro	ORF1a	Cell line		View
19	39259728	R222L	Mpro	ORF1a	Cell line		View
20	39259728	S144A	Mpro	ORF1a	Cell line	D	View
21	39259728	T198I	Mpro	ORF1a	Cell line	D	View
22	39259728	T21I	Mpro	ORF1a	Cell line	D	View
23	39259728	T304I	Mpro	ORF1a	Cell line		View
24	39259728	Y54H	Mpro	ORF1a	Cell line	D	View
25	39424074	E166A	Mpro	ORF1a	Cell line	D	View
26	39424074	E166V	Mpro	ORF1a	Cell line	D	View
27	39424074	L167F	Mpro	ORF1a	Cell line	D	View
28	39424074	L50F	Mpro	ORF1a	Cell line	D	View
29	39424074	S144A	Mpro	ORF1a	Cell line	D	View
30	37957287	E290A	Mpro	ORF1a	Cell line	R	View
31	37957287	C145A	Mpro	ORF1a	Cell line	R	View
32	37957287	R298A	Mpro	ORF1a	Cell line	R	View
33	39319611	E166V	Mpro	ORF1a	Cell line	D	View
34	39319611	L50F	Mpro	ORF1a	Cell line	D	View
35	39319611	T21I	Mpro	ORF1a	Cell line	D	View
36	37390404	E166V	Mpro	ORF1a	Cell line	D S	View
37	38762033	E290A	Mpro	ORF1a			View
38	38762033	G11A	Mpro	ORF1a			View
39	38762033	R298A	Mpro	ORF1a			View
40	32853525	D48E	Mpro	ORF1a		S	View
41	32853525	M17I	Mpro	ORF1a		S	View
42	37651467	N142A	Mpro	ORF1a		G	View
43	37651467	P132H	Mpro	ORF1a		G	View
44	37651467	E166D	Mpro	ORF1a			View
45	37651467	E166N	Mpro	ORF1a			View
46	37651467	E166R	Mpro	ORF1a		D	View
47	37651467	C145A	Mpro	ORF1a			View
48	37651467	E166A	Mpro	ORF1a		D	View
49	37651467	E166V	Mpro	ORF1a		D	View
50	38257765	D48N	Mpro	ORF1a			View
51	36467259	S147A	Mpro	ORF1a			View
52	36467259	A267S	Mpro	ORF1a			View
53	36467259	A46S	Mpro	ORF1a			View
54	36467259	H134F	Mpro	ORF1a			View
55	36467259	I286L	Mpro	ORF1a			View
56	36467259	K180N	Mpro	ORF1a			View
57	36467259	L202V	Mpro	ORF1a			View
58	36467259	L86V	Mpro	ORF1a			View
59	36467259	R88K	Mpro	ORF1a			View
60	36467259	S65N	Mpro	ORF1a			View
61	36467259	S94A	Mpro	ORF1a			View
62	36467259	T285A	Mpro	ORF1a			View
63	36467259	T35V	Mpro	ORF1a			View
64	35461811	P132H	Mpro	ORF1a	COVID-19	G	View
65	36368287	P132H	Mpro	ORF1a	COVID-19	G	View
66	35461811	G15S	Mpro	ORF1a	COVID-19	G	View
67	35461811	K90R	Mpro	ORF1a	COVID-19	G	View
68	39990941	A173V	Mpro	ORF1a	COVID-19	D	View
69	39990941	E166V	Mpro	ORF1a	COVID-19	D	View
70	39990941	L50F	Mpro	ORF1a	COVID-19	D	View
71	39990941	T190I	Mpro	ORF1a	COVID-19		View
72	39990941	T21I	Mpro	ORF1a	COVID-19		View
73	36775130	G143S	Mpro	ORF1a	COVID-19		View
74	36775130	M49I	Mpro	ORF1a	COVID-19		View
75	36775130	Q189K	Mpro	ORF1a	COVID-19		View
76	36775130	R188S	Mpro	ORF1a	COVID-19		View
77	36775130	M49T	Mpro	ORF1a	COVID-19		View
78	36775130	N142S	Mpro	ORF1a	COVID-19		View
79	36775130	N142D	Mpro	ORF1a	COVID-19		View
80	36775130	M165I	Mpro	ORF1a	COVID-19		View
81	36775130	R188K	Mpro	ORF1a	COVID-19		View
82	36775130	T190I	Mpro	ORF1a	COVID-19		View
83	36775130	A191T	Mpro	ORF1a	COVID-19		View
84	36775130	A191V	Mpro	ORF1a	COVID-19		View
85	36775130	A193S	Mpro	ORF1a	COVID-19		View
86	36775130	A193T	Mpro	ORF1a	COVID-19		View
87	36775130	A193V	Mpro	ORF1a	COVID-19		View
88	37271339	C145A	Mpro	ORF1a	COVID-19		View
89	37271339	E290A	Mpro	ORF1a	COVID-19		View
90	37271339	H41A	Mpro	ORF1a	COVID-19		View
91	37271339	R298A	Mpro	ORF1a	COVID-19		View
92	39712205	A173V	Mpro	ORF1a	COVID-19		View
93	39712205	A285V	Mpro	ORF1a	COVID-19	D	View
94	39712205	E166V	Mpro	ORF1a	COVID-19	D	View
95	39712205	K90R	Mpro	ORF1a	COVID-19	D	View
96	39712205	L27V	Mpro	ORF1a	COVID-19		View
97	39712205	N142S	Mpro	ORF1a	COVID-19		View
98	39712205	P132H	Mpro	ORF1a	COVID-19	D	View
99	39712205	Y154N	Mpro	ORF1a	COVID-19		View
100	39893201	A191V	Mpro	ORF1a	COVID-19		View
101	39893201	A193P	Mpro	ORF1a	COVID-19		View
102	39893201	C145A	Mpro	ORF1a	COVID-19		View
103	39893201	E166A	Mpro	ORF1a	COVID-19		View
104	39893201	E166V	Mpro	ORF1a	COVID-19	D	View
105	39893201	L167F	Mpro	ORF1a	COVID-19	D	View
106	39893201	L50A	Mpro	ORF1a	COVID-19		View
107	39893201	L50F	Mpro	ORF1a	COVID-19	D	View
108	39893201	P252L	Mpro	ORF1a	COVID-19	D	View
109	39893201	Q256L	Mpro	ORF1a	COVID-19		View
110	39893201	T21I	Mpro	ORF1a	COVID-19	D	View
111	39893201	T304I	Mpro	ORF1a	COVID-19	D	View
112	40133408	E166N	Mpro	ORF1a	COVID-19		View
113	40133408	E166R	Mpro	ORF1a	COVID-19		View
114	40133408	E166V	Mpro	ORF1a	COVID-19		View
115	40133408	H163A	Mpro	ORF1a	COVID-19		View
116	40133408	S144A	Mpro	ORF1a	COVID-19		View
117	40183562	E166A	Mpro	ORF1a	COVID-19	D	View
118	40183562	E166V	Mpro	ORF1a	COVID-19	D	View
119	40183562	L50F	Mpro	ORF1a	COVID-19		View
120	33649700	Y54C	Mpro	ORF1a	COVID-19		View
121	33649700	N142S	Mpro	ORF1a	COVID-19		View
122	33649700	T190I	Mpro	ORF1a	COVID-19		View
123	33649700	A191V	Mpro	ORF1a	COVID-19		View
124	32984400	C145A	Mpro	ORF1a	COVID-19		View
125	34399606	C300S	Mpro	ORF1a	COVID-19		View
126	32881907	R60C	Mpro	ORF1a	COVID-19	R	View
127	33894500	I152V	Mpro	ORF1a	COVID-19		View
128	33894500	R60C	Mpro	ORF1a	COVID-19		View
129	39259728	P132H	Mpro	ORF1a	Cell line	G	View