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Virus Gene/Protein ORF1a ORF1b ORF3a S E M N ORF7a ORF7b ORF8 ORF1ab ORF9b ORF10 ORF6 ORF9c

Disease COVID-19 Cell line Cystic Fibrosis Pediatric Multisystem Inflammatory Disease, COVID-19 related Thrombosis, COVID-19 related HIV Infections

Description Genotype/Subtype Immune Target gene Clinical data Treatment Location Sequence data

For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a

  

ORF1b

  

ORF3a

  

3CLpro

  

3'UTR

  

5'UTR

  

RBD

  

ORF7b-ORF8

  

upstream of N

  

Furin cleavage site

  

E

  

endoRNase

  

Exonuclease

  

S

  

NSP13

  

NSP3

  

M

  

Mpro

  

Methyltransferase

  

N

  

NSP14

  

NSP12

  

Non-coding region

  

NP

  

NS3

  

NS7a

  

NS7b

  

NS8

  

NSP5

  

NSP1

  

NSP10

  

NSP11

  

NSP15

  

NSP16

  

NSP2

  

NSP4

  

NSP6

  

NSP7

  

NSP8

  

NSP9

  

NTD

  

ORF8

  

ORF1ab

  

ORF9b

  

ORF10

  

ORF3

  

ORF6

  

ORF7a

  

ORF7b

  

ORF9

  

ORF9c

  

PLpro

  

RdRp

  

RBM

  

Replicase

  

RNA primase

  

• Mutation
• Sequence

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	37929963	P323L	NSP12	ORF1b	Cell line	R T	View
2	38415690	K417G	NSP12	ORF1b	COVID-19 Cell line	G R S	View
3	38415690	K478R	NSP12	ORF1b	COVID-19 Cell line	G R S	View
4	38990941	V330S	NSP12	ORF1b			View
5	38990941	V341S	NSP12	ORF1b			View
6	38990941	D760A	NSP12	ORF1b			View
7	38990941	D761A	NSP12	ORF1b			View
8	38990941	D499G	NSP12	ORF1b			View
9	38990941	M668V	NSP12	ORF1b			View
10	38990941	V560A	NSP12	ORF1b			View
11	34141447	P323L	NSP12	ORF1b			View
12	39584063	C14408T	NSP12	ORF1b		R	View
13	35321260	P323L	NSP12	ORF1b		G	View
14	35733956	P323L	NSP12	ORF1b		G R	View
15	35733956	H613Y	NSP12	ORF1b		G R	View
16	35906172	F192V	NSP12	ORF1b		G L	View
17	36512569	T15096C	NSP12	ORF1b		G R L	View
18	36512569	N543N	NSP12	ORF1b		G R L	View
19	35547225	P314L	NSP12	ORF1b		S L	View
20	35547225	P4804P	NSP12	ORF1b		S L	View
21	38476954	P314F	NSP12	ORF1b	COVID-19	G R S L	View
22	38276171	N215D	NSP12	ORF1b	COVID-19	G R S L	View
23	33391880	A656S	NSP12	ORF1b	COVID-19	G R S L	View
24	33391880	P323L	NSP12	ORF1b	COVID-19	G R S L	View
25	34834948	P323L	NSP12	ORF1b	COVID-19	G R S L	View
26	35128118	G823S	NSP12	ORF1b	COVID-19	G R L	View
27	39836474	G671S	NSP12	ORF1b	COVID-19	D G R	View
28	35966679	G671S	NSP12	ORF1b	COVID-19	G L	View
29	36590492	P323L	NSP12	ORF1b	COVID-19	G R S L	View
30	36590492	G671S	NSP12	ORF1b	COVID-19	G R S L	View
31	36354320	E83D	NSP12	ORF1b	COVID-19	G R S C L	View
32	38605705	G14181C	NSP12	ORF1b	COVID-19	G R S C L	View
33	38605705	L247F	NSP12	ORF1b	COVID-19	G R S C L	View
34	37086978	823insD	NSP12	ORF1b	COVID-19	G R	View
35	37086978	G671S	NSP12	ORF1b	COVID-19	G R	View
36	37086978	P323L	NSP12	ORF1b	COVID-19	G R	View
37	37224159	C14408T	NSP12	ORF1b	COVID-19	G R L	View
38	37224159	G15451A	NSP12	ORF1b	COVID-19	G R L	View
39	37224159	C15714T	NSP12	ORF1b	COVID-19	G R L	View
40	37224159	G662S	NSP12	ORF1b	COVID-19	G R L	View
41	37224159	L749L	NSP12	ORF1b	COVID-19	G R L	View
42	37224159	P314L	NSP12	ORF1b	COVID-19	G R L	View
43	37086978	Y273H	NSP12	ORF1b	COVID-19	G R	View
44	37086978	V405F	NSP12	ORF1b	COVID-19	G R	View
45	37799539	P323L	NSP12	ORF1b	COVID-19	G R C L	View
46	37630656	A449V	NSP12	ORF1b	COVID-19	G R S C	View
47	35966679	A423V	NSP12	ORF1b	COVID-19	G I L	View
48	33549572	P323L	NSP12	ORF1b	COVID-19	G R	View
49	35966679	P323L	NSP12	ORF1b	COVID-19	G L	View
50	36778569	P323L	NSP12	ORF1b	COVID-19	G R S L	View
51	33201914	C14408T	NSP12	ORF1b	COVID-19	G R L	View
52	33201914	P323L	NSP12	ORF1b	COVID-19	G R L	View
53	32823907	C14408T	NSP12	ORF1b	COVID-19	G R S L	View
54	32823907	P323L	NSP12	ORF1b	COVID-19	G R S L	View
55	35992703	T76I	NSP12	ORF1b	COVID-19	G L	View
56	35992703	L638F	NSP12	ORF1b	COVID-19	G L	View
57	35992703	P227L	NSP12	ORF1b	COVID-19	G L	View
58	35992703	T26I	NSP12	ORF1b	COVID-19	G L	View
59	35992703	G108V	NSP12	ORF1b	COVID-19	G L	View
60	33572190	P323L	NSP12	ORF1b	COVID-19	G R L	View
61	33572190	C14408T	NSP12	ORF1b	COVID-19	G R L	View
62	37630656	D67N	NSP12	ORF1b	COVID-19	G R S C	View
63	38605705	C14408T	NSP12	ORF1b	COVID-19	G R S C L	View
64	38605705	A14673G	NSP12	ORF1b	COVID-19	G R S C L	View
65	38605705	C15026T	NSP12	ORF1b	COVID-19	G R S C L	View
66	38605705	C15714T	NSP12	ORF1b	COVID-19	G R S C L	View
67	38605705	P323L	NSP12	ORF1b	COVID-19	G R S C L	View
68	38605705	A529V	NSP12	ORF1b	COVID-19	G R S C L	View
69	37086978	A529V	NSP12	ORF1b	COVID-19	G R	View
70	37529147	P314L	NSP12	ORF1b	COVID-19	R S L	View
71	38668234	P314L	NSP12	ORF1b	COVID-19	R C L	View
72	32595352	P323L	NSP12	ORF1b	COVID-19	R	View
73	32595352	C14805T	NSP12	ORF1b	COVID-19	R	View
74	39145418	P323L	NSP12	ORF1b	COVID-19		View
75	39774959	G671S	NSP12	ORF1b	COVID-19		View
76	40100755	G671S	NSP12	ORF1b	COVID-19		View
77	35215919	T293I	NSP12	ORF1b	COVID-19	S	View
78	35482820	V792I	NSP12	ORF1b	COVID-19	D	View
79	35482820	C799F	NSP12	ORF1b	COVID-19		View
80	35482820	C799R	NSP12	ORF1b	COVID-19		View
81	35482820	N198S	NSP12	ORF1b	COVID-19		View
82	35482820	V166A	NSP12	ORF1b	COVID-19		View
83	35996593	V792I	NSP12	ORF1b	COVID-19	R L	View
84	36090111	A302A	NSP12	ORF1b	COVID-19	R C L	View
85	36090111	D51Y	NSP12	ORF1b	COVID-19	R C L	View
86	36090111	G662S	NSP12	ORF1b	COVID-19	R C L	View
87	36090111	H604H	NSP12	ORF1b	COVID-19	R C L	View
88	36090111	N543N	NSP12	ORF1b	COVID-19	R C L	View
89	36090111	P314L	NSP12	ORF1b	COVID-19	R C L	View
90	36090111	P403P	NSP12	ORF1b	COVID-19	R C L	View
91	36560780	P323L	NSP12	ORF1b	COVID-19		View
92	36687433	P323L	NSP12	ORF1b	COVID-19	R S L	View
93	36841805	P323L	NSP12	ORF1b	COVID-19	R	View
94	36915185	P323L	NSP12	ORF1b	COVID-19	R L	View
95	35538682	P323L	NSP12	ORF1b	COVID-19	L	View
96	35552003	P314L	NSP12	ORF1b	COVID-19	R L	View
97	35614572	P323L	NSP12	ORF1b	COVID-19	R	View
98	35614572	T739I	NSP12	ORF1b	COVID-19	R	View
99	35707000	A423V	NSP12	ORF1b	COVID-19	R	View
100	35707000	C14408T	NSP12	ORF1b	COVID-19	R	View
101	35707000	C14708T	NSP12	ORF1b	COVID-19	R	View
102	35707000	P323L	NSP12	ORF1b	COVID-19	R	View
103	35707124	P323L	NSP12	ORF1b	COVID-19	R L	View
104	35759503	Y479N	NSP12	ORF1b	COVID-19	R L	View
105	35913920	A97V	NSP12	ORF1b	COVID-19	R	View
106	35913920	P323L	NSP12	ORF1b	COVID-19	R	View
107	32972934	K59N	NSP12	ORF1b	COVID-19	S L	View
108	32972934	P323L	NSP12	ORF1b	COVID-19	S L	View
109	33384909	M4588I	NSP12	ORF1b	COVID-19	R	View
110	33384909	T4418I	NSP12	ORF1b	COVID-19	R	View
111	33384909	T5195I	NSP12	ORF1b	COVID-19	R	View
112	35891618	N386N	NSP12	ORF1b	COVID-19	S L	View
113	35891618	P323L	NSP12	ORF1b	COVID-19	S L	View
114	36672914	P323L	NSP12	ORF1b	COVID-19	C L	View
115	36672914	F283S	NSP12	ORF1b	COVID-19	C L	View
116	39294134	C464Y	NSP12	ORF1b	COVID-19	D R S C L	View
117	39294134	C799Y	NSP12	ORF1b	COVID-19	D R S C L	View
118	39294134	E136A	NSP12	ORF1b	COVID-19	R S C L	View
119	39294134	E796K	NSP12	ORF1b	COVID-19	R S C L	View
120	39294134	M794I	NSP12	ORF1b	COVID-19	D R S C L	View
121	39294134	Q444K	NSP12	ORF1b	COVID-19	R S C L	View
122	39294134	T643I	NSP12	ORF1b	COVID-19	R S C L	View
123	39294134	V166L	NSP12	ORF1b	COVID-19	R S C L	View
124	39294134	V223I	NSP12	ORF1b	COVID-19	R S C L	View
125	39294134	V792I	NSP12	ORF1b	COVID-19	D R S C L	View
126	39294134	V820G	NSP12	ORF1b	COVID-19	R S C L	View
127	39836474	A97V	NSP12	ORF1b	COVID-19	R	View
128	39836474	C799F	NSP12	ORF1b	COVID-19	R	View
129	39836474	E802D	NSP12	ORF1b	COVID-19	R	View
130	39836474	K59N	NSP12	ORF1b	COVID-19	R	View
131	39836474	L838I	NSP12	ORF1b	COVID-19	R	View
132	39836474	P227L	NSP12	ORF1b	COVID-19	R	View
133	39836474	P323L	NSP12	ORF1b	COVID-19	D R	View
134	39836474	S759A	NSP12	ORF1b	COVID-19	R	View
135	39836474	V166A	NSP12	ORF1b	COVID-19	R	View
136	39836474	V166L	NSP12	ORF1b	COVID-19	R	View
137	39836474	V557L	NSP12	ORF1b	COVID-19	R	View
138	39836474	V792I	NSP12	ORF1b	COVID-19	R	View
139	39861827	C14599T	NSP12	ORF1b	COVID-19	R L	View
140	39970290	P323L	NSP12	ORF1b	COVID-19	R L	View
141	40006937	C14408T	NSP12	ORF1b	COVID-19	S L	View
142	40160532	M794I	NSP12	ORF1b	COVID-19	D L	View
143	40160532	V792I	NSP12	ORF1b	COVID-19	D L	View
144	33347622	P314L	NSP12	ORF1b	COVID-19		View
145	33558859	P323L	NSP12	ORF1b	COVID-19	R L	View
146	34534263	E802D	NSP12	ORF1b	COVID-19	D R	View
147	34663909	C14408T	NSP12	ORF1b	COVID-19		View
148	34663909	P323L	NSP12	ORF1b	COVID-19		View
149	35499994	P323L	NSP12	ORF1b	COVID-19	L	View
150	37466213	A125A	NSP12	ORF1b	COVID-19	D R C L	View
151	37466213	A125T	NSP12	ORF1b	COVID-19	D R C L	View
152	37466213	A16V	NSP12	ORF1b	COVID-19	D R C L	View
153	37466213	A176A	NSP12	ORF1b	COVID-19	D R C L	View
154	37466213	A176V	NSP12	ORF1b	COVID-19	D R C L	View
155	37466213	A311A	NSP12	ORF1b	COVID-19	D R C L	View
156	37466213	A311E	NSP12	ORF1b	COVID-19	D R C L	View
157	37466213	A311T	NSP12	ORF1b	COVID-19	D R C L	View
158	37466213	A382A	NSP12	ORF1b	COVID-19	D R C L	View
159	37466213	A382V	NSP12	ORF1b	COVID-19	D R C L	View
160	37466213	A423A	NSP12	ORF1b	COVID-19	D R C L	View
161	37466213	A423V	NSP12	ORF1b	COVID-19	D R C L	View
162	37466213	A771A	NSP12	ORF1b	COVID-19	D R C L	View
163	37466213	A771P	NSP12	ORF1b	COVID-19	D R C L	View
164	37466213	A97A	NSP12	ORF1b	COVID-19	D R C L	View
165	37466213	A97S	NSP12	ORF1b	COVID-19	D R C L	View
166	37466213	C799C	NSP12	ORF1b	COVID-19	D R C L	View
167	37466213	C799F	NSP12	ORF1b	COVID-19	D R C L	View
168	37466213	D291D	NSP12	ORF1b	COVID-19	D R C L	View
169	37466213	D291N	NSP12	ORF1b	COVID-19	D R C L	View
170	37466213	D60D	NSP12	ORF1b	COVID-19	D R C L	View
171	37466213	D60H	NSP12	ORF1b	COVID-19	D R C L	View
172	37466213	D684D	NSP12	ORF1b	COVID-19	D R C L	View
173	37466213	D684N	NSP12	ORF1b	COVID-19	D R C L	View
174	37466213	F56F	NSP12	ORF1b	COVID-19	D R C L	View
175	37466213	F56S	NSP12	ORF1b	COVID-19	D R C L	View
176	37466213	F843F	NSP12	ORF1b	COVID-19	D R C L	View
177	37466213	F843L	NSP12	ORF1b	COVID-19	D R C L	View
178	37466213	G345G	NSP12	ORF1b	COVID-19	D R C L	View
179	37466213	G345V	NSP12	ORF1b	COVID-19	D R C L	View
180	37466213	G427G	NSP12	ORF1b	COVID-19	D R C L	View
181	37466213	G427V	NSP12	ORF1b	COVID-19	D R C L	View
182	37466213	G44G	NSP12	ORF1b	COVID-19	D R C L	View
183	37466213	G44V	NSP12	ORF1b	COVID-19	D R C L	View
184	37466213	G823C	NSP12	ORF1b	COVID-19	D R C L	View
185	37466213	G823G	NSP12	ORF1b	COVID-19	D R C L	View
186	37466213	K59K	NSP12	ORF1b	COVID-19	D R C L	View
187	37466213	K59N	NSP12	ORF1b	COVID-19	D R C L	View
188	37466213	L707F	NSP12	ORF1b	COVID-19	D R C L	View
189	37466213	L707L	NSP12	ORF1b	COVID-19	D R C L	View
190	37466213	N403I	NSP12	ORF1b	COVID-19	D R C L	View
191	37466213	N403N	NSP12	ORF1b	COVID-19	D R C L	View
192	37466213	P227P	NSP12	ORF1b	COVID-19	D R C L	View
193	37466213	P323L	NSP12	ORF1b	COVID-19	D R C L	View
194	37466213	P323P	NSP12	ORF1b	COVID-19	D R C L	View
195	37466213	P830P	NSP12	ORF1b	COVID-19	D R C L	View
196	37466213	P830S	NSP12	ORF1b	COVID-19	D R C L	View
197	37466213	P832P	NSP12	ORF1b	COVID-19	D R C L	View
198	37466213	P832S	NSP12	ORF1b	COVID-19	D R C L	View
199	37466213	Q444H	NSP12	ORF1b	COVID-19	D R C L	View
200	37466213	Q444Q	NSP12	ORF1b	COVID-19	D R C L	View
201	37466213	Q524Q	NSP12	ORF1b	COVID-19	D R C L	View
202	37466213	R733I	NSP12	ORF1b	COVID-19	D R C L	View
203	37466213	R733R	NSP12	ORF1b	COVID-19	D R C L	View
204	37466213	S425P	NSP12	ORF1b	COVID-19	D R C L	View
205	37466213	S425S	NSP12	ORF1b	COVID-19	D R C L	View
206	37466213	S501L	NSP12	ORF1b	COVID-19	D R C L	View
207	37466213	S759A	NSP12	ORF1b	COVID-19	D R C L	View
208	37466213	T20T	NSP12	ORF1b	COVID-19	D R C L	View
209	37466213	T324I	NSP12	ORF1b	COVID-19	D R C L	View
210	37466213	T324T	NSP12	ORF1b	COVID-19	D R C L	View
211	37466213	T567I	NSP12	ORF1b	COVID-19	D R C L	View
212	37466213	T567T	NSP12	ORF1b	COVID-19	D R C L	View
213	37466213	T701M	NSP12	ORF1b	COVID-19	D R C L	View
214	37466213	T701T	NSP12	ORF1b	COVID-19	D R C L	View
215	37466213	V315F	NSP12	ORF1b	COVID-19	D R C L	View
216	37466213	V315V	NSP12	ORF1b	COVID-19	D R C L	View
217	37466213	V359I	NSP12	ORF1b	COVID-19	D R C L	View
218	37466213	V359V	NSP12	ORF1b	COVID-19	D R C L	View
219	37466213	V764L	NSP12	ORF1b	COVID-19	D R C L	View
220	37466213	V764V	NSP12	ORF1b	COVID-19	D R C L	View
221	37466213	V792I	NSP12	ORF1b	COVID-19	D R C L	View
222	37466213	Y483H	NSP12	ORF1b	COVID-19	D R C L	View
223	37466213	Y483Y	NSP12	ORF1b	COVID-19	D R C L	View
224	37466213	Y719C	NSP12	ORF1b	COVID-19	D R C L	View
225	37466213	Y719Y	NSP12	ORF1b	COVID-19	D R C L	View
226	32793182	P314L	NSP12	ORF1b	COVID-19	R	View
227	33184173	C14408T	NSP12	ORF1b	COVID-19		View
228	33184173	P4715L	NSP12	ORF1b	COVID-19		View
229	33920487	A185S	NSP12	ORF1b	COVID-19	R	View
230	33920487	V776L	NSP12	ORF1b	COVID-19	R	View
231	34468954	Q444H	NSP12	ORF1b	COVID-19	R C L	View
232	36145442	P323L	NSP12	ORF1b	COVID-19		View
233	36354320	A13535G	NSP12	ORF1b	COVID-19	R S C L	View
234	36354320	Y32C	NSP12	ORF1b	COVID-19	R S C L	View
235	36354320	C13551T	NSP12	ORF1b	COVID-19	R S C L	View
236	36354320	G13564T	NSP12	ORF1b	COVID-19	R S C L	View
237	36354320	V42L	NSP12	ORF1b	COVID-19	R S C L	View
238	36354320	A13689T	NSP12	ORF1b	COVID-19	R S C L	View
239	36354320	A13711G	NSP12	ORF1b	COVID-19	R S C L	View
240	36354320	K91G	NSP12	ORF1b	COVID-19	R S C L	View
241	36354320	C14119T	NSP12	ORF1b	COVID-19	R S C L	View
242	36354320	C14120T	NSP12	ORF1b	COVID-19	R S C L	View
243	36354320	P227L	NSP12	ORF1b	COVID-19	R S C L	View
244	36354320	C14178T	NSP12	ORF1b	COVID-19	R S C L	View
245	36354320	C14547A	NSP12	ORF1b	COVID-19	R S C L	View
246	36354320	C14703T	NSP12	ORF1b	COVID-19	R S C L	View
247	36354320	T422I	NSP12	ORF1b	COVID-19	R S C L	View
248	36354320	C15237T	NSP12	ORF1b	COVID-19	R S C L	View
249	36354320	C15240T	NSP12	ORF1b	COVID-19	R S C L	View
250	36354320	C15324T	NSP12	ORF1b	COVID-19	R S C L	View
251	36354320	C15441T	NSP12	ORF1b	COVID-19	R S C L	View
252	36354320	G15627T	NSP12	ORF1b	COVID-19	R S C L	View
253	36354320	E729D	NSP12	ORF1b	COVID-19	R S C L	View
254	36354320	C15652T	NSP12	ORF1b	COVID-19	R S C L	View
255	36354320	D738Y	NSP12	ORF1b	COVID-19	R S C L	View
256	36354320	G15910T	NSP12	ORF1b	COVID-19	R S C L	View
257	36354320	C15952A	NSP12	ORF1b	COVID-19	R S C L	View
258	36354320	L838I	NSP12	ORF1b	COVID-19	R S C L	View
259	36819024	A185V	NSP12	ORF1b	COVID-19	L	View
260	36819024	V381A	NSP12	ORF1b	COVID-19	L	View
261	36819024	P323L	NSP12	ORF1b	COVID-19	L	View
262	38684722	W162G	NSP12	ORF1b	COVID-19	S C L	View
263	38684722	Y163F	NSP12	ORF1b	COVID-19	S C L	View
264	38684722	I307L	NSP12	ORF1b	COVID-19	S C L	View
265	38684722	C464Y	NSP12	ORF1b	COVID-19	S C L	View
266	38684722	C464F	NSP12	ORF1b	COVID-19	S C L	View
267	38684722	M519T	NSP12	ORF1b	COVID-19	S C L	View
268	38684722	G671S	NSP12	ORF1b	COVID-19	S C L	View
269	38684722	Y748N	NSP12	ORF1b	COVID-19	S C L	View
270	38684722	L749M	NSP12	ORF1b	COVID-19	S C L	View
271	38684722	A777S	NSP12	ORF1b	COVID-19	S C L	View
272	38684722	V792I	NSP12	ORF1b	COVID-19	D S C L	View
273	38684722	M794I	NSP12	ORF1b	COVID-19	D S C L	View
274	38684722	C799R	NSP12	ORF1b	COVID-19	D S C L	View
275	38684722	C799F	NSP12	ORF1b	COVID-19	S C L	View
276	38684722	C813R	NSP12	ORF1b	COVID-19	S C L	View
277	38435775	P323L	NSP12	ORF1b	COVID-19	C L	View
278	38435775	Q468H	NSP12	ORF1b	COVID-19	C L	View
279	38435775	G671S	NSP12	ORF1b	COVID-19	C L	View
280	36504602	P323L	NSP12	ORF1b	COVID-19	C L	View
281	32595352	C14408T	NSP12	ORF1b	COVID-19	R	View
282	34917639	P323L	NSP12	ORF1b	COVID-19	R S L	View
283	39836474	A449V	NSP12	ORF1b	COVID-19	R	View
284	37676771	G671S	NSP12	ORF1b	Cell line	G R S	View
285	37676771	P323L	NSP12	ORF1b	Cell line	G R S	View