All Curated Mutation Sites in HIV 
Back to Mutation Home

 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in HIV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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Keyword: Nef
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 39612239 A83G
Nef
Nef
HIV Infections
D
G
R
L
T
View
2 39612239 D108E
Nef
Nef
HIV Infections
D
G
R
L
T
View
3 39612239 E179N
Nef
Nef
HIV Infections
G
R
L
T
View
4 39612239 E63G
Nef
Nef
HIV Infections
D
G
R
L
T
View
5 39612239 F81Y
Nef
Nef
HIV Infections
G
R
L
T
View
6 39612239 G63E
Nef
Nef
HIV Infections
G
R
L
T
View
7 39612239 R105K
Nef
Nef
HIV Infections
D
G
R
L
T
View
8 39612239 R178G
Nef
Nef
HIV Infections
G
R
L
T
View
9 39612239 S88G
Nef
Nef
HIV Infections
G
R
I
L
T
View
10 39612239 V16I
Nef
Nef
HIV Infections
G
R
I
L
T
View
11 22643973 P69S
Nef
Nef

G
R
I
View
12 22643973 V66A
Nef
Nef

G
R
I
View
13 22643973 V66G
Nef
Nef

G
R
I
View
14 22643973 V70G
Nef
Nef

G
R
I
View
15 33109760 D111A
Nef
Nef
Acquired Immunodeficiency Syndrome
D
G
I
View
16 33109760 G2A
Nef
Nef
Acquired Immunodeficiency Syndrome
D
G
I
View
17 33109760 I109A
Nef
Nef
Acquired Immunodeficiency Syndrome
D
G
I
View
18 33109760 I114A
Nef
Nef
Acquired Immunodeficiency Syndrome
D
G
I
View
19 33109760 L110A
Nef
Nef
Acquired Immunodeficiency Syndrome
D
G
I
View
20 33109760 L112A
Nef
Nef
Acquired Immunodeficiency Syndrome
D
G
I
View
21 33109760 Y115A
Nef
Nef
Acquired Immunodeficiency Syndrome
D
G
I
View
22 30201008 H89Y
Nef
Nef
HIV Infections
G
R
S
I
C
L
T
View
23 30201008 V133I
Nef
Nef
HIV Infections
G
R
S
I
C
L
T
View
24 30201008 V133T
Nef
Nef
HIV Infections
G
R
S
I
C
L
T
View
25 30201008 Y81F
Nef
Nef
HIV Infections
G
R
S
I
C
L
T
View
26 30249546 R71K
Nef
Nef
HIV Infections
G
L
View
27 30249546 T80D
Nef
Nef
HIV Infections
G
L
View
28 30249546 Y135F
Nef
Nef
HIV Infections
G
L
View
29 30249546 Y135L
Nef
Nef
HIV Infections
G
L
View
30 30249546 Y81F
Nef
Nef
HIV Infections
G
L
View
31 22651890 D123E
Nef
Nef
Cell line
G
View
32 22651890 F68A
Nef
Nef
Cell line
G
View
33 22651890 F90A
Nef
Nef
Cell line
G
View
34 22651890 G67A
Nef
Nef
Cell line
G
View
35 22651890 L76V
Nef
Nef
Cell line
G
View
36 22651890 P69A
Nef
Nef
Cell line
G
View
37 22651890 P72A
Nef
Nef
Cell line
G
View
38 22651890 P72G
Nef
Nef
Cell line
G
View
39 22651890 P75A
Nef
Nef
Cell line
G
View
40 22651890 P75G
Nef
Nef
Cell line
G
View
41 22651890 P78A
Nef
Nef
Cell line
G
View
42 22651890 P78G
Nef
Nef
Cell line
G
View
43 22651890 Q73R
Nef
Nef
Cell line
G
View
44 22651890 R77K
Nef
Nef
Cell line
G
View
45 22651890 V66A
Nef
Nef
Cell line
G
View
46 22651890 V74I
Nef
Nef
Cell line
G
View
47 31262272 A15E
Nef
Nef
HIV Infections
G
R
S
C
L
View
48 31262272 A15S
Nef
Nef
HIV Infections
G
R
S
C
L
View
49 31262272 C8S
Nef
Nef
HIV Infections
G
R
S
C
L
View
50 31262272 D24A
Nef
Nef
HIV Infections
G
R
S
C
L
View
51 31262272 D24G
Nef
Nef
HIV Infections
G
R
S
C
L
View
52 31262272 K105N
Nef
Nef
HIV Infections
G
R
S
C
L
View
53 31262272 K105T
Nef
Nef
HIV Infections
G
R
S
C
L
View
54 31262272 K118E
Nef
Nef
HIV Infections
G
R
S
C
L
View
55 31262272 K118R
Nef
Nef
HIV Infections
G
R
S
C
L
View
56 31262272 K7N
Nef
Nef
HIV Infections
G
R
S
C
L
View
57 31262272 L20A
Nef
Nef
HIV Infections
G
R
S
C
L
View
58 31262272 L20I
Nef
Nef
HIV Infections
G
R
S
C
L
View
59 31262272 L20R
Nef
Nef
HIV Infections
G
R
S
C
L
View
60 31262272 R19A
Nef
Nef
HIV Infections
G
R
S
C
L
View
61 31262272 R19P
Nef
Nef
HIV Infections
G
R
S
C
L
View
62 31262272 V11G
Nef
Nef
HIV Infections
G
R
S
C
L
View
63 31262272 V11P
Nef
Nef
HIV Infections
G
R
S
C
L
View
64 31262272 W5Q
Nef
Nef
HIV Infections
G
R
S
C
L
View
65 31262272 W5R
Nef
Nef
HIV Infections
G
R
S
C
L
View
66 31693887 E94K
Nef
Nef
HIV Infections
G
R
S
C
L
View
67 31693887 H116N
Nef
Nef
HIV Infections
G
R
S
I
C
L
View
68 31693887 I114V
Nef
Nef
HIV Infections
G
R
S
C
L
View
69 31693887 I43V
Nef
Nef
HIV Infections
G
R
S
C
L
View
70 31693887 K92R
Nef
Nef
HIV Infections
G
R
S
C
L
View
71 31693887 K94E
Nef
Nef
HIV Infections
G
R
S
I
C
L
View
72 31693887 N51T
Nef
Nef
HIV Infections
G
R
S
C
L
View
73 31693887 S163C
Nef
Nef
HIV Infections
G
R
S
C
L
View
74 31693887 S163R
Nef
Nef
HIV Infections
G
R
S
C
L
View
75 31693887 V148L
Nef
Nef
HIV Infections
G
R
S
C
L
View
76 31736889 G2A
Nef
Nef
HIV Infections
G
View
77 32106437 C9063T
Nef
Nef
HIV Infections
D
G
R
S
C
L
View
78 30808702 C206X
Nef
Nef
Cell line
G
R
S
View
79 30808702 E59K
Nef
Nef
Cell line
G
R
S
View
80 32179688 I123L
Nef
Nef
HIV Infections
D
G
L
View
81 32179688 L146F
Nef
Nef
HIV Infections
D
G
L
View
82 31186327 D123A
Nef
Nef
Cell line
G
S
View
83 31186327 D174K
Nef
Nef
Cell line
G
S
View
84 31186327 E160A
Nef
Nef
Cell line
G
S
View
85 31186327 F121A
Nef
Nef
Cell line
G
S
View
86 31186327 F191I
Nef
Nef
Cell line
G
S
View
87 31186327 G2A
Nef
Nef
Cell line
G
S
View
88 31186327 L112A
Nef
Nef
Cell line
G
S
View
89 31186327 P72A
Nef
Nef
Cell line
G
S
View
90 31266880 C200A
Nef
Nef
Cell line
D
G
R
View
91 31266880 D186N
Nef
Nef
Cell line
D
G
R
View
92 31266880 G267A
Nef
Nef
Cell line
D
G
R
View
93 31266880 T318G
Nef
Nef
Cell line
D
G
R
View
94 32925973 G11V
Nef
Nef
HIV Infections
D
G
S
L
View
95 32925973 I11G
Nef
Nef
HIV Infections
D
G
S
L
View
96 32925973 K94E
Nef
Nef
HIV Infections
D
G
S
L
View
97 32925973 S8R
Nef
Nef
HIV Infections
D
G
S
L
View
98 32925973 V11G
Nef
Nef
HIV Infections
D
G
S
L
View
99 32960906 H116N
Nef
Nef
HIV Infections
D
G
R
L
View
100 32960906 K94E
Nef
Nef
HIV Infections
D
G
R
L
View
101 32960906 L58V
Nef
Nef
HIV Infections
D
G
R
L
View
102 32960906 R22Q
Nef
Nef
HIV Infections
D
G
R
L
View
103 33146906 12_39del
Nef
Nef
HIV Infections
D
G
I
View
104 33146906 F195A
Nef
Nef
HIV Infections
G
I
View
105 33173092 Q125H
Nef
Nef
HIV Infections
D
G
S
I
L
View
106 33173092 Y120F
Nef
Nef
HIV Infections
D
G
S
L
View
107 33787846 T71R
Nef
Nef
HIV Infections
D
G
View
108 33800773 H116N
Nef
Nef
HIV Infections
G
L
View
109 33800773 M168I
Nef
Nef
HIV Infections
G
L
View
110 33800773 M168X
Nef
Nef
HIV Infections
G
L
View
111 33800773 N51T
Nef
Nef
HIV Infections
G
L
View
112 33800773 R178G
Nef
Nef
HIV Infections
G
L
View
113 33800773 S163C
Nef
Nef
HIV Infections
G
L
View
114 33800773 V148L
Nef
Nef
HIV Infections
G
L
View
115 33800773 V148X
Nef
Nef
HIV Infections
G
L
View
116 17311088 A83G
Nef
Nef
HIV Infections
G
R
S
L
View
117 17311088 E98D
Nef
Nef
HIV Infections
G
R
S
I
L
View
118 17311088 L87I
Nef
Nef
HIV Infections
G
R
S
L
View
119 17311088 R184K
Nef
Nef
HIV Infections
G
R
S
I
L
View
120 17311088 V85L
Nef
Nef
HIV Infections
G
R
S
L
View
121 36130828 Y139F
Nef
Nef
HIV Infections
D
I
View
Contents
Description

The table shows all curated mutation sites of HIV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.