Gene Name	ERBB2
Gene ID	2064
Gene Full Name	erb-b2 receptor tyrosine kinase 2
Gene Alias	CD340|HER-2|HER-2/neu|HER2|MLN 19|MLN-19|NEU|NGL|TKR1|VSCN2|c-ERB-2|c-ERB2|p185(erbB2)
Transcripts	ENSG00000141736
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Plasma membrane;Nucleoplasm, Cytosol;
Membrane Info	Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P04626
HGNC ID	HGNC:3430
OMIM ID	164870
Summary	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5000185	chr17	131	426	185	742	View
5000545	chr17	114	25	1	140	View
5000588	chr17	115	11	0	126	View
5000589	chr17	115	11	0	126	View
5000590	chr17	114	12	0	126	View
5000772	chr17	80	7	0	87	View
5002776	chr17	7	1	0	8	View
5007005	chr17	238	214	55	507	View
5007006	chr17	243	168	49	460	View
5007007	chr17	85	4	0	89	View
5007008	chr17	666	4	3	673	View
5007009	chr17	767	14	21	802	View
5007010	chr17	41	10	19	70	View
5007011	chr17	79	3	0	82	View
5007012	chr17	4	0	0	4	View
5007013	chr17	4	1	0	5	View
5009857	chr17	1	2	0	3	View
5009858	chr17	31	6	0	37	View
5012919	chr17	51	3	0	54	View
5012920	chr17	118	7	1	126	View
5012921	chr17	714	64	4	782	View
5012922	chr17	2564	484	183	3231	View
5012923	chr17	2562	483	184	3229	View
5012924	chr17	309	15	4	328	View
5012925	chr17	366	38	5	409	View
5012926	chr17	226	91	47	364	View
5012927	chr17	50	6	1	57	View
5012928	chr17	289	54	12	355	View
5012929	chr17	2	3	0	5	View
5012930	chr17	17	2	7	26	View
5012934	chr17	4456	1906	1063	7425	View
5012935	chr17	4449	1918	1068	7435	View
5012936	chr17	4151	3127	1551	8829	View
5015165	chr17	4	0	0	4	View
5015166	chr17	1	0	0	1	View
5015167	chr17	150	10	1	161	View
5015168	chr17	364	125	68	557	View
5015169	chr17	2	31	10	43	View
5015170	chr17	724	67	4	795	View
5015171	chr17	1419	1139	545	3103	View
5015172	chr17	2042	754	262	3058	View
5015173	chr17	1453	81	140	1674	View
5015174	chr17	820	12	1	833	View
5015175	chr17	59	3	0	62	View
5015176	chr17	48	2	0	50	View
5015177	chr17	19	3	0	22	View
5015178	chr17	102	88	38	228	View
5015179	chr17	288	766	75	1129	View
5015180	chr17	413	194	73	680	View
5015181	chr17	119	274	74	467	View
5015182	chr17	336	14	5	355	View
5015183	chr17	26	10	0	36	View
5015184	chr17	38	6	0	44	View
5015185	chr17	73	1	0	74	View
5015186	chr17	79	10	0	89	View
5015187	chr17	2	4	1	7	View
5015188	chr17	76	81	77	234	View
5015189	chr17	9	14	1	24	View
5015190	chr17	8	16	1	25	View
5015191	chr17	20	76	6	102	View
5015192	chr17	30	7	0	37	View
5015193	chr17	57	18	0	75	View
5015194	chr17	428	82	0	510	View
5015195	chr17	565	96	0	661	View
5015196	chr17	935	94	22	1051	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE40774	Expression array	134	Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE164690	scRNA-seq	51	Illumina NextSeq 500 (Homo sapiens)
GSE138080	Expression array	35	Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE197461	scRNA-seq	16	Illumina NovaSeq 6000 (Homo sapiens)
GSE199029	Variation;RNA-seq	44	NanoString Human nCounter PanCancer IO360 Panel
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE183048 - ERBB2 peak across samples

Peak Plot

> Dataset: GSE143026 - ERBB2 peak across samples

Peak Plot