Gene Information
|
Gene Name
|
NHERF1 |
|
Gene ID
|
9368
|
|
Gene Full Name
|
NHERF family PDZ scaffold protein 1 |
|
Gene Alias
|
EBP50|NHE-RF|NHERF|NHERF-1|NPHLOP2|SLC9A3R1 |
|
Transcripts
|
ENSG00000109062
|
|
Virus
|
HIV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Plasma membrane, Centriolar satellite;Basal body, Cytosol, Calyx; 
|
|
Membrane Info
|
Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
|
Uniport_ID
|
O14745
|
|
HGNC ID
|
HGNC:11075
|
|
OMIM ID
|
604990 |
|
Summary
|
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009] |
Target gene [NHERF1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 4001439 |
chr17 |
16 |
87 |
62 |
165 |
View |
| 4012465 |
chr17 |
5 |
0 |
0 |
5 |
View |
Target gene [NHERF1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE220859
|
Chip-seq |
11 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE128121
|
RNA-seq |
16 |
Illumina HiSeq 4000 (Homo sapiens) |
|
C GSE211651
|
Chip-seq;RNA-seq;PRO-seq |
39 |
Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE162914
|
RNA-seq |
211 |
Illumina HiSeq 2500 (Homo sapiens) |
|
E GSE144332
|
RNA-seq |
75 |
NextSeq 550 (Homo sapiens) |
|
GSE68028
|
MeDIP-chip |
1 |
NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1] |
|
C GSE165705
|
Chip-seq |
30 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE165703
|
ATAC-seq |
82 |
Illumina HiSeq 4000 (Homo sapiens) |
|
C GSE144329
|
ATAC-seq |
96 |
NextSeq 550 (Homo sapiens) |
|
GSE205204
|
RNA-seq |
14 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE167211
|
RNA-seq |
1 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE246082
|
RNA-seq |
6 |
Illumina HiSeq 4000 (Homo sapiens) |
|
C GSE100266
|
ATAC-seq;Chip-seq;RNA-seq |
32 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE125686
|
RNA-seq |
62 |
Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
GSE164264
|
RNA-seq |
6 |
BGISEQ-500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: GSE144332 - NHERF1 expression across samples
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Volcano Plot
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Bar Plot
|
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HIV Target gene Detail Information
