| Accession |
GSE167211
|
| Status |
2021/5/11 |
| Title |
Mechanisms of Th17 and Treg cell dysregulation in oral mucosal inflammation during HIV disease |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing |
| Summary |
Purpose: The goal of this study is to compare the transcriptomic profiles of healthy individuals and HIV+ patients on therapy
Methods: Cells were pelleted from gingival mucosa. mRNA profiles were generated by Next-gen sequencing using the Illumina platform.
Results: Comprehensive transcriptome data that showed underlying changes in the oral mucosal immune system of HIV+ patients on therapy. The transcriptome data of the pooled healthy controls are presented here.
Conclusions: Our study represents the analysis of oral gingival transcriptomes. We conclude that RNA-seq based transcriptome characterization would expedite genetic network analyses and permit the dissection of complex biological functional alterations during chronic viral infections such as HIV infection. |
| Samples |
| GSM ID |
Sample info |
Characteristics |
Description |
|
GSM5099597
|
Pooled samples from 3 biological replicates of healthy controls- Group 1 |
disease state:healthy; tissue:gingival mucosa; age:52 |
Median age is provided here |
|
| Platform |
GPL11154 : Illumina HiSeq 2000 (Homo sapiens) |
| Literature |
34446704 36693889 |
| Download |
Download xCell Data Download Expression Analysis Data
|
|
xCell Plot
|
|
* p<0.05 ** p<0.01
|
Virus Dataset Detail
