Virus Dataset Detail

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Dataset Information
Accession GSE205204
Status 2022/6/5
Title Comprehensive RNA-Seq Reveals Molecular Changes in Kidney Malignancy Among People Living with HIV
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To heighten the awareness of kidney malignancy in patients with HIV infection to facilitate the early diagnosis of kidney cancer, the differentially expressed mRNAs were analyzed in this malignant tumor using RNA sequencing (RNA-seq). We identified 2962 protein-coding transcripts in HIV-associated kidney cancer. KISS1R, CAIX, and NPTX2 mRNA expression levels were specifically increased in HIV-associated kidney cancer, and UMOD and TMEM213 mRNA were decreased in most cases based on real-time PCR analyses. These findings were similar to those noted for the general population with renal cell carcinoma. Immunohistochemical staining analysis also showed that a total of 16 of 18 malignant kidney cases among PLWH exhibited positive staining for KISS1R and CAIX. Pathway analysis of the differentially expressed mRNAs in HIV-associated kidney cancer revealed that several key pathways were involved, including vascular endothelial growth factor-activated receptor activity, IgG binding, and lipopolysaccharide receptor activity. Altogether, our findings reveal the identified molecular changes in kidney malignancy, which may offer a helpful explanation for cancer progression and open up new therapeutic avenues that may decrease mortality after a cancer diagnosis among PLWH.
Samples
GSM ID Sample info Characteristics Description
GSM6208552 JF-Paracancerous tissue:Paracancerous tissue1; gender:male; age:60y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208553 JF-Tumor tissue:Kidney Malignancy with HIV tissue1; gender:male; age:60y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208554 WKD-Paracancerous tissue:Paracancerous tissue2; gender:male; age:48y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208555 WKD-Tumor tissue:Kidney Malignancy with HIV tissue2; gender:male; age:48y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208556 ZZM-Paracancerous tissue:Paracancerous tissue3; gender:male; age:65y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208557 ZZM-Tumor tissue:Kidney Malignancy with HIV tissue3; gender:male; age:65y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208558 YHZ Paracancerous tissue:Paracancerous tissue4; gender:male; age:59y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208559 YHZ_Tumor tissue:Kidney Malignancy with HIV tissue4; gender:male; age:59y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208560 XC_Paracancerous tissue:Paracancerous tissue5; gender:male; age:65y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208561 XC_ Tumor tissue:Kidney Malignancy with HIV tissue5; gender:male; age:65y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208562 LKQ_Paracancerous tissue:Paracancerous tissue6; gender:male; age:63y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208563 LKQ_Tumor tissue:Kidney Malignancy with HIV tissue6; gender:male; age:63y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208564 ZFM_Paracancerous tissue:Paracancerous tissue7; gender:male; age:50y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
GSM6208565 ZFM_ Tumor tissue:Kidney Malignancy with HIV tissue7; gender:male; age:50y Gene expression data from Paracancerous tissue lower than Kidney Malignancy with HIV tissue
Platform GPL24676  : Illumina NovaSeq 6000 (Homo sapiens)
Literature 35795483  
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* p<0.05 ** p<0.01